Synthetic peptide immunorphin as an instrument of the study of nonopioid β-endorphin receptor

Research results of the synthetic decapeptide SLTCLVKGFY (the author's term is immunorphin) corresponding to the 364-373 sequence of G heavy-chain human immunoglobulin are summarized. Special attention is paid to the interaction between immunorphin and nonopioid (insensitive to the opioid antag...

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Bibliographic Details
Published in:	Russian journal of bioorganic chemistry Vol. 36; no. 1; pp. 40 - 48
Main Authors:	Kovalitskaya, Yu. A, Navolotskaya, E. V
Format:	Journal Article
Language:	English
Published:	Dordrecht Dordrecht : SP MAIK Nauka/Interperiodica 2010 SP MAIK Nauka/Interperiodica
Subjects:	Biochemistry Biomedical and Life Sciences Biomedicine Bioorganic Chemistry embryos immune-competent cell Life Sciences membranes naloxone-insensitive binding site Organic Chemistry Reviews synthetic peptides β-endorphin naloxone-insensitive binding site membranes synthetic peptides β embryos immune-competent cell
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Summary:	Research results of the synthetic decapeptide SLTCLVKGFY (the author's term is immunorphin) corresponding to the 364-373 sequence of G heavy-chain human immunoglobulin are summarized. Special attention is paid to the interaction between immunorphin and nonopioid (insensitive to the opioid antagonist naloxone) β-endorphin receptor. Using radioligand analysis, data were found regarding the distribution and functions of nonopioid β-endorphin receptor in human and animal bodies and the binding characteristics of immunorphin with nonopioid receptor.
Bibliography:	http://dx.doi.org/10.1134/S106816201001005X
ISSN:	1068-1620 1608-330X
DOI:	10.1134/S106816201001005X