The receptor antagonist picotamide inhibits adrenergic and thromboxane-induced contraction of hyperplastic human prostate smooth muscle

Inhibition of prostate smooth muscle contraction is an important strategy for medical treatment of lower urinary tract symptoms (LUTS). Besides α1-adrenoceptors, prostate smooth muscle contraction is induced by activation of thromboxane (TXA2) receptors (TXA2-R). Here, we examined the effects of the...

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Bibliographic Details
Published in:	American journal of physiology. Renal physiology Vol. 305; no. 10; p. F1383
Main Authors:	Hennenberg, Martin, Miljak, Marijan, Herrmann, Daniel, Strittmatter, Frank, Walther, Sebastian, Rutz, Beata, Hocaoglu, Yasemin, Kunit, Thomas, Schreiber, Andrea, Andersson, Karl-Erik, Stief, Christian G, Gratzke, Christian
Format:	Journal Article
Language:	English
Published:	United States 15-11-2013
Subjects:	Adrenergic Agonists - pharmacology Adrenergic alpha-1 Receptor Antagonists - pharmacology Dose-Response Relationship, Drug Electric Stimulation Humans Male Muscle Contraction - drug effects Muscle, Smooth - drug effects Muscle, Smooth - innervation Muscle, Smooth - metabolism Phthalic Acids - pharmacology Prostaglandin Antagonists - pharmacology Prostate - drug effects Prostate - innervation Prostate - metabolism Receptors, Adrenergic, alpha-1 - drug effects Receptors, Adrenergic, alpha-1 - metabolism Receptors, Thromboxane A2, Prostaglandin H2 - antagonists & inhibitors Receptors, Thromboxane A2, Prostaglandin H2 - metabolism Signal Transduction - drug effects Thromboxane-A Synthase - metabolism Thromboxanes - pharmacology picotamide smooth muscle contraction lower urinary tract symptoms α1-adrenoceptor benign prostate hyperplasia
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