Brazil nut–enriched diet modulates bone mineral density and body composition in an experimental model of chronic kidney disease

• Published in: Nutrition (Burbank, Los Angeles County, Calif.) Vol. 125; p. 112482
• Main Authors: Da Cruz, Beatriz Oliveira, Almeida, Patricia Pereira, Silva-Costa, Nathalia, Brito, Michele Lima, Degani, Viviane Alexandre Nunes, da Silva, Eduardo Moreira, Magliano, D'Angelo Carlo, Mebarek, Saida, Brizuela, Leyre, Cardozo, Ludmila F.M.F., Stockler-Pinto, Milena Barcza
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01-09-2024; Elsevier Limited
• Subjects: Animal models; Animals; Antioxidants; Biomechanics; Biometrics; Body composition; Body fat; Bone composition; Bone density; Bone mass; Bone mineral density; bone parameters; Brazil nut; Calcium; Chronic illnesses; chronic kidney disease; Composition effects; Diet; Dual energy X-ray absorptiometry; Enrichment; Food; Fractures; Kidney diseases; Metabolism; Mineralization; Nutrition research; Nuts; Osteoporosis; Parameters; Selenium; Uremia; Brazil; United States > US; Brazil nut; dual-energy X-ray absorptiometry; chronic kidney disease; bone parameters
• ISSN: 0899-9007; 1873-1244; 1873-1244
• DOI: 10.1016/j.nut.2024.112482

•Chronic kidney disease promotes mineral and bone metabolism disorders.•Food natural bioactive compounds hold promise in chronic kidney disease treatment and demonstrate potential benefits in enhancing body composition.•Brazil nut–enriched diet induced a higher total body bone mineral density in nephrectomized rats.
This study investigates the effects of a Brazil nut-enriched diet on body composition and bone parameters in CKD animal model.
Male Wistar rats were assigned to the following groups: Sham (n=8), Nx (n=6), nephrectomized rats, and NxBN (n=6), nephrectomized rats and an enricheddiet with 5% Brazil nut. Body composition parameters were obtained by dual-energy X- ray absorptiometry (DXA). Bioclin kits determined plasmatic calcium. The femurs werecollected to determine absolute mass and length, bone mineral density, and biomechanical tests.
The NxBN group exhibited a higher total body bone mineral density (BMD) value than the Nx group (0.177±0.004g/cm2vs 0,169±0.003g/cm2; p=0.0397). No significant differences were observed regarding absolute mass, length, BMD, and biomechanical parameters in the femurs of the groups. Moreover, no significant differences were found in plasmatic calcium levels among the groups.
Brazil-nut enriched diet modulated BMD in CKD experimental model, and further studies are demanded to understand the pathways involved in this finding.