Outcome of renal grafts after simultaneous kidney/pancreas transplantation

• Published in: Diabetologia Vol. 34; no. S1; pp. S16 - S17
• Main Authors: HILLEBRAND, G, ILLNER, W.-D, ABENDROTH, D, SCHNEEBERGER, H, PETRY, I, SCHLEIBNER, S, LANDGRAF, R, LAND, W
• Format: Conference Proceeding Journal Article
• Language: English
• Published: Berlin Springer 01-08-1991
• Subjects: Biological and medical sciences; Diabetes Mellitus, Type 1 - surgery; Diabetic Nephropathies - surgery; Graft Rejection; Graft Survival; Humans; Immunosuppression - methods; Kidney Failure, Chronic - surgery; Kidney Transplantation - methods; Kidney Transplantation - physiology; Medical sciences; Pancreas Transplantation - methods; Pancreas Transplantation - physiology; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of endocrine glands; Treatment Outcome
• ISSN: 0012-186X; 1432-0428
• DOI: 10.1007/BF00587611

Nineteen patients with endstage renal failure due to Type 1 (insulin-dependent) diabetes mellitus received simultaneous pancreas/kidney transplants using bladder drainage technique. Another group of 25 Type 1 diabetic patients received pancreas/kidney transplants by the duct occlusion technique. We observed a higher incidence of rejection episodes in the patients of the bladder drainage group than those in the duct occlusion group, 14 of 19 patients (74%) vs 7 of 25 (28%) respectively. Anti CD3 antibodies (OrthocloneR, OKT3) as a part of induction treatment was used more often in the bladder drainage group (58%) than in the control group (20%).