Bilirubin : A natural inhibitor of vascular smooth muscle cell proliferation

Bilirubin, a natural product of heme catabolism by heme oxygenases, was considered a toxic waste product until 1987, when its antioxidant potential was recognized. On the basis of observations that oxidative stress is a potent trigger in vascular proliferative responses, that heme oxygenase-1 is ant...

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Bibliographic Details
Published in:	Circulation (New York, N.Y.) Vol. 112; no. 7; pp. 1030 - 1039
Main Authors:	ÖLLINGER, Robert, BILBAN, Martin, OTTERBEIN, Leo E, USHEVA, Anny, YAMASHITA, Kenichiro, BACH, Fritz H, ERAT, Anna, FROIO, Alberto, MCDAID, James, TYAGI, Shivraj, CSIZMADIA, Eva, GRACA-SOUZA, Aurelio V, LILOIA, Angela, SCARES, Miguel P
Format:	Journal Article
Language:	English
Published:	Hagerstown, MD Lippincott Williams & Wilkins 16-08-2005
Subjects:	Animals Atherosclerosis (general aspects, experimental research) Bilirubin - pharmacology Biliverdine - pharmacology Biological and medical sciences Blood and lymphatic vessels Blood vessels and receptors Cardiology. Vascular system Cell Differentiation - drug effects Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Fundamental and applied biological sciences. Psychology Male Medical sciences Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - drug effects Rats Rats, Gunn Rats, Inbred Lew Rats, Wistar Vertebrates: cardiovascular system Cell proliferation arteriosclerosis muscle, smooth Cell cycle Cardiovascular disease Smooth muscle Bilirubin signal transition
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