The screening of Chinese crude drugs for Ca2+ antagonist activity: identification of active principles from the aerial part of Pogostemon cablin and the fruits of Prunus mume

Hot aqueous extracts of 134 Chinese crude drugs were subjected to screening for inhibitory activity on K+ contracture of guinea pig taenia coli, and significant activity was observed in 17 crude drugs. Chemical investigations of two crude drugs, Kakko and Ubai, which originate from Pogostemon cablin...

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Bibliographic Details
Published in:	Chemical & pharmaceutical bulletin Vol. 37; no. 2; pp. 345 - 348
Main Authors:	ICHIKAWA, K, KINOSHITA, T, SANKAWA, U
Format:	Journal Article
Language:	English
Published:	Tokyo Maruzen 01-02-1989
Subjects:	Animals Biological and medical sciences Calcium Channel Blockers Digestive system Drugs, Chinese Herbal - pharmacology Guinea Pigs In Vitro Techniques Medical sciences Muscle, Smooth - drug effects Pharmacology. Drug treatments Plants, Medicinal - analysis Rats Rats, Inbred Strains Folk medicine Asia Digestive system China Calcium antagonist Plant origin Smooth muscle Active ingredient Muscle contraction Medicinal plant
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Summary:	Hot aqueous extracts of 134 Chinese crude drugs were subjected to screening for inhibitory activity on K+ contracture of guinea pig taenia coli, and significant activity was observed in 17 crude drugs. Chemical investigations of two crude drugs, Kakko and Ubai, which originate from Pogostemon cablin and Prunus mume, respectively, were undertaken, and patchouli alcohol (I) and 5-(hydroxymethyl)-2-furaldehyde (II) were identified as their active principles, respectively.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.37.345