Biological activities and chemical composition of crude extracts from Chresta exsucca

Biological activities and chemical composition of crude extracts from Chresta exsucca

Crude extracts of Chresta exsucca were investigated for their in vitro trypanocidal, leishmanicidal, antibacterial and antifungal activities. Trypomastigote forms of Trypanosoma cruzi, amastigote-like forms of Leishmania amazonensis and twenty strains of microorganisms including Gram-positive and Gr...

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Bibliographic Details
Published in:Revista brasileira de ciências farmacêuticas Vol. 42; no. 1; pp. 83 - 90
Main Authors: Schinor, Elisandra Cristina, Salvador, Marcos José, Tomaz, José Carlos, Pral, Elizabeth Mieko Furusho, Alfieri, Silvia Celina, Albuquerque, Sérgio de, Ito, Izabel Yoko, Dias, Diones Aparecida
Format: Journal Article
Language:English
Published: Divisão de Biblioteca e Documentação do Conjunto das Químicas da Universidade de São Paulo 01-03-2006
Subjects:
PHARMACOLOGY & PHARMACY
HPLC-ESI-MS
Biological activities
Atividades biológicas
Chresta exsucca
Asteraceae
HRGC
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Summary:Crude extracts of Chresta exsucca were investigated for their in vitro trypanocidal, leishmanicidal, antibacterial and antifungal activities. Trypomastigote forms of Trypanosoma cruzi, amastigote-like forms of Leishmania amazonensis and twenty strains of microorganisms including Gram-positive and Gram-negative bacteria and yeasts were utilized in the bioassays. The best results were found for the leishmanicidal activity. The chemical composition of hexanic and ethanolic extracts of this species was determinate using chromatographic techniques as HRGC and HPLC-ESI-MS, respectively. Steroids, triterpenes and flavonoids were identified.
ISSN:1516-9332
DOI:10.1590/S1516-93322006000100009