Effects of SR 48692, a selective non-peptide neurotensin receptor antagonist, on two dopamine-dependent behavioural responses in mice and rats

• Published in: Psychopharmacologia Vol. 116; no. 2; pp. 237 - 241
• Main Authors: PONCELET, M, SOUILHAC, J, GUEUDET, C, TERRANOVA, J. P, GULLY, D, LE FUR, G, SOUBRIE, P
• Format: Journal Article
• Language: English
• Published: Berlin Springer 01-10-1994
• Subjects: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine - antagonists & inhibitors; 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine - pharmacology; Animals; Apomorphine - antagonists & inhibitors; Apomorphine - pharmacology; Behavior, Animal - drug effects; Behavioral psychophysiology; Biological and medical sciences; Bromocriptine - antagonists & inhibitors; Bromocriptine - pharmacology; Dopamine - physiology; Dose-Response Relationship, Drug; Female; Fundamental and applied biological sciences. Psychology; Male; Mice; Motor Activity - drug effects; Neurotransmission and behavior; Penile Erection - drug effects; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Pyrazoles - pharmacology; Quinolines - pharmacology; Rats; Rats, Wistar; Receptors, Neurotensin - antagonists & inhibitors; Stereotyped Behavior - drug effects; Yawning - drug effects; Vertebrata; Mammalia; Dopamine; Rat; Mouse; Dopamine receptor; Animal; Neuromediator; Rodentia; Behavior; Neurotensin; Catecholamine
• DOI: 10.1007/BF02245067
• EISSN: 1432-2072
• ISSN: 0033-3158

One major mechanism underlying the central action of neurotensin is an interaction with the function of dopamine (DA)-containing neurons. In addition, direct or indirect DA agonists have been reported to promote neurotensin release. We have found that SR 48692, a non-peptide neurotensin receptor antagonist (0.04-0.64 mg/kg orally), antagonizes (50-65%) yawning induced by apomorphine (0.07 mg/kg SC) or bromocriptine (2 mg/kg IP) in rats, and turning behaviour induced by intrastriatal injection of apomorphine (0.25 micrograms), (+) SKF 38393 (0.1 micrograms), bromocriptine (0.01 ng) or (+) amphetamine (10 micrograms) in mice. Other apomorphine-induced effects in mice and rats such as climbing, hypothermia, hypo- and hyper-locomotion, penile erections and stereotypies were not significantly modified by SR 48692. Taken together, these data suggest that neurotensin may play a permissive role in the expression of some but not all behavioural responses to DA receptor stimulation.