Premarital Screening is Pivotal in Reducing the Births of Babies Affected with Thalassemia Major in Iraq

• Published in: Hemoglobin Vol. 48; no. 1; pp. 56 - 59
• Main Authors: Khoshnaw, Najmaddin S H, Omar, Jawhar J, Hussein, Zahir S, Mohammed, Rebar N
• Format: Journal Article
• Language: English
• Published: England 2024
• Subjects: premarital screening; Hemoglobinopathies; β-thalassemia trait; Iraq; Kurdistan
• DOI: 10.1080/03630269.2024.2325456
• EISSN: 1532-432X
• ISSN: 0363-0269

Thalassemia major is one of the health problems in Iraq, especially in Kurdistan. Pre-marriage mandatory preventive screening program was established in Kurdistan in 2008, which allowed us to study the prevalence of different hemoglobinopathies among newly married young adults in this region. A total of 1154 subjects (577 couples) attending the Koya district, premarital Health center, were screened using red cell indices. Those who had mean corpuscular volume (MCV)<80 fl and mean corpuscular hemoglobin (MCH)<27 pg had high-performance liquid chromatography and iron studies. Out of 1154 individuals that were evaluated, 183 (11.9%) had low MCV and MCH. Of the former 183 subjects, 69 (5.97%) had β-thalassemia trait, 10 (0.86%) had δβ-thalassemia trait, and no other hemoglobinopathies were recorded in our study. There was second-degree consanguinity in 4.7% of all 577 couples. In two couples, both partners had β-thalassemia trait and both were consanguineous. Both couples decided to separate after counseling. Based on the current study, the role of the premarital screening program in decreasing the number of new thalassemia major cases among the Kurdish population is laudable. Therefore, mandatory premarital screening is advised in all parts of Iraq.