Differences in Cardiovascular Risk Factors, Insulin Resistance, and Insulin Secretion in Individuals With Normal Glucose Tolerance and in Subjects With Impaired Glucose Regulation

• Published in: Diabetes care Vol. 28; no. 10; pp. 2388 - 2393
• Main Authors: Nóvoa, Francisco J., Boronat, Mauro, Saavedra, Pedro, Díaz-Cremades, Juan M., Varillas, Valois F., La Roche, Fátima, Alberiche, María P., Carrillo, Armando
• Format: Journal Article
• Language: English
• Published: American Diabetes Association 01-10-2005
• ISSN: 0149-5992; 1935-5548
• DOI: 10.2337/diacare.28.10.2388

Differences in Cardiovascular Risk Factors, Insulin Resistance, and Insulin Secretion in Individuals With Normal Glucose Tolerance
and in Subjects With Impaired Glucose Regulation
The Telde Study
Francisco J. Nóvoa , MD, PHD 1 ,
Mauro Boronat , MD 1 ,
Pedro Saavedra , PHD 2 ,
Juan M. Díaz-Cremades , MD, PHD 3 ,
Valois F. Varillas , MD 4 ,
Fátima La Roche , MD 1 ,
María P. Alberiche , MD 1 and
Armando Carrillo , MD 1
1 Endocrinology and Nutrition Section, Hospital Universitario Insular, Las Palmas de Gran Canaria, Spain
2 Mathematics Department, University of Las Palmas, Las Palmas de Gran Canaria, Spain
3 Hematology Service, Hospital Universitario Insular, Las Palmas de Gran Canaria, Spain
4 Hospital General de Fuerteventura, Puerto del Rosario, Las Palmas, Spain
Address correspondence and reprint requests to Francisco J. Nóvoa, Endocrinology and Nutrition Section, Hospital Universitario
Insular, Las Palmas de Gran Canaria 35016, Spain. E-mail: fnovoa{at}dcmq.ulpgc.es
Abstract
OBJECTIVE —To assess the cardiovascular risk profile, the degree of insulin resistance, and β-cell secretion in a cohort of subjects
with different categories of impaired glucose regulation (IGR): impaired fasting glucose (IFG), impaired glucose tolerance
(IGT), and combined IFG/IGT.
RESEARCH DESIGN AND METHODS —We studied 902 nondiabetic subjects between 30 and 80 years of age, recruited from a cross-sectional population-based study
in Telde, Gran Canaria Island, Spain. Categories of glucose tolerance were defined according to 2003 modified American Diabetes
Association criteria. Risk factors for cardiovascular disease, the presence of the metabolic syndrome, and indirect measures
of both insulin resistance and β-cell function were analyzed.
RESULTS —A total of 132 (14.6%) participants had isolated IFG, 59 (6.5%) isolated IGT, and 48 (5.3%) combined IFG/IGT. Groups with
normal glucose tolerance (NGT) and combined IFG/IGT had, respectively, the most favorable and unfavorable levels of cardiovascular
risk factors, metabolic syndrome rates, and measures of insulin resistance. Subjects with IFG and IGT showed an intermediate
profile between NGT and IFG/IGT categories. We found no significant differences between IFG and IGT in cardiovascular risk
factors, metabolic syndrome prevalence, or insulin resistance. The IFG group exhibited a more impaired insulin secretion than
those with IGT or IFG/IGT.
CONCLUSIONS —Individuals with IGR, especially those with IFG/IGT, have increased values of cardiovascular risk factors and higher indexes
of insulin resistance. Groups with isolated IFG and isolated IGT present similar cardiovascular risk profiles. Subjects with
IFG are characterized by more defective β-cell function than other forms of IGR.
ADA, American Diabetes Association
CVD, cardiovascular disease
FPG, fasting plasma glucose
HOMA-IR, homeostasis model assessment for insulin resistance
IFG, impaired fasting glucose
IGR, impaired glucose regulation
IGT, impaired glucose tolerance
NGT, normal glucose tolerance
OGTT, oral glucose tolerance test
PAI-1, plasminogen activator inhibitor-1
QUICKI, quantitative insulin-sensitivity check index
Footnotes
A table elsewhere in this issue shows conventional and Système International (SI) units and conversion factors for many substances.
Accepted July 18, 2005.
Received May 16, 2005.
DIABETES CARE