Methylenetetrahydrofolate reductase and glutathione S-tranferase gene polymorphisms in secondary mixed phenotype acute leukemia: a case report
Therapy-induced leukemia is a well-known clinical syndrome occurring as a late complication in patients treated with cytotoxic therapy. We herein present results of analysis of common gene polymorphisms in methylenetetrahydrofolate reductase (MTHFR) and glutathione S-transferase (GST) genes in a 10-...
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| Published in: | Journal of pediatric hematology/oncology Vol. 36; no. 3; pp. e152 - e154 |
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United States
01-04-2014
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| Abstract | Therapy-induced leukemia is a well-known clinical syndrome occurring as a late complication in patients treated with cytotoxic therapy.
We herein present results of analysis of common gene polymorphisms in methylenetetrahydrofolate reductase (MTHFR) and glutathione S-transferase (GST) genes in a 10-year-old boy who developed very rare type of cancer, mixed phenotype acute leukemia, 6 years after treatment of acute lymphoblastic leukemia.
Impairment in function of GST and MTHFR enzymes found in our patient may have contributed to the development of secondary mixed phenotype acute leukemia, although precise mechanism remains elusive. |
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| AbstractList | BACKGROUNDTherapy-induced leukemia is a well-known clinical syndrome occurring as a late complication in patients treated with cytotoxic therapy.OBSERVATIONWe herein present results of analysis of common gene polymorphisms in methylenetetrahydrofolate reductase (MTHFR) and glutathione S-transferase (GST) genes in a 10-year-old boy who developed very rare type of cancer, mixed phenotype acute leukemia, 6 years after treatment of acute lymphoblastic leukemia.CONCLUSIONSImpairment in function of GST and MTHFR enzymes found in our patient may have contributed to the development of secondary mixed phenotype acute leukemia, although precise mechanism remains elusive. Therapy-induced leukemia is a well-known clinical syndrome occurring as a late complication in patients treated with cytotoxic therapy. We herein present results of analysis of common gene polymorphisms in methylenetetrahydrofolate reductase (MTHFR) and glutathione S-transferase (GST) genes in a 10-year-old boy who developed very rare type of cancer, mixed phenotype acute leukemia, 6 years after treatment of acute lymphoblastic leukemia. Impairment in function of GST and MTHFR enzymes found in our patient may have contributed to the development of secondary mixed phenotype acute leukemia, although precise mechanism remains elusive. |
| Author | Ivana, Joksic Petar, Ivanovski Tanja, Radic Tatjana, Simic Skoric, Dejan Jovana, Jakovljevic |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/24276031$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/S0076-6879(05)01002-5 10.3109/10409239509083491 10.1111/j.1365-2141.2007.06613.x 10.1002/mpo.1127 |
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| References | Seedhouse (R19-26-20210227) 2007; 137 Bowen (R10-26-20210227) 2012; 79 Hayes (R12-26-20210227) 1995; 30 Perentesis (R16-26-20210227) 2001; 36 Coles (R15-26-20210227) 2005; 401 |
| References_xml | – volume: 401 start-page: 9 year: 2005 ident: R15-26-20210227 article-title: Human alpha class glutathione S-transferases: genetic polymorphisms, expression, and susceptibility to disease. publication-title: Methods Enzymol doi: 10.1016/S0076-6879(05)01002-5 contributor: fullname: Coles – volume: 30 start-page: 445 year: 1995 ident: R12-26-20210227 article-title: The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. publication-title: Crit Rev Biochem Mol Biol doi: 10.3109/10409239509083491 contributor: fullname: Hayes – volume: 137 start-page: 513 year: 2007 ident: R19-26-20210227 article-title: Advances in understanding of susceptibility to treatment related acute myeloid leukemia. publication-title: Brit J Haematol doi: 10.1111/j.1365-2141.2007.06613.x contributor: fullname: Seedhouse – volume: 79 start-page: 949 year: 2012 ident: R10-26-20210227 article-title: Factor V leiden (G1691A), the prothrombin 3-untranslated region variant (G20210A) and thermolabile methylenetetrahydrofolate reductase (C677T): a single genetic test genotypes all three locidetermination of frequencies in the S. Wales population of the UK. publication-title: Thromb Haemost contributor: fullname: Bowen – volume: 36 start-page: 41 year: 2001 ident: R16-26-20210227 article-title: Genetic predisposition and treatment related leukemia. publication-title: Med Pediatr Oncol doi: 10.1002/mpo.1127 contributor: fullname: Perentesis |
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| Snippet | Therapy-induced leukemia is a well-known clinical syndrome occurring as a late complication in patients treated with cytotoxic therapy.
We herein present... BACKGROUNDTherapy-induced leukemia is a well-known clinical syndrome occurring as a late complication in patients treated with cytotoxic therapy.OBSERVATIONWe... |
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| SubjectTerms | Acute Disease Biomarkers, Tumor - genetics Child Flow Cytometry Genotype Glutathione S-Transferase pi - genetics Glutathione Transferase - genetics Humans Leukemia - drug therapy Leukemia - genetics Male Methylenetetrahydrofolate Reductase (NADPH2) - genetics Neoplasms, Second Primary - drug therapy Neoplasms, Second Primary - genetics Phenotype Polymerase Chain Reaction Polymorphism, Genetic - genetics Polymorphism, Restriction Fragment Length Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Prognosis Remission Induction |
| Title | Methylenetetrahydrofolate reductase and glutathione S-tranferase gene polymorphisms in secondary mixed phenotype acute leukemia: a case report |
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