An evaluation of the interaction of pixantrone with formaldehyde-releasing drugs in cancer cells

Purpose Pixantrone is a synthetic aza-anthracenedione currently used in the treatment of non-Hodgkin’s lymphoma. The drug is firmly established as a poison of the nuclear enzyme topoisomerase II, however, pixantrone can also generate covalent drug-DNA adducts following activation by formaldehyde. Wh...

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Bibliographic Details
Published in:	Cancer chemotherapy and pharmacology Vol. 89; no. 6; pp. 773 - 784
Main Authors:	Mansour, Oula C., Nudelman, Abraham, Rephaeli, Ada, Phillips, Don R., Cutts, Suzanne M., Evison, Benny J.
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer Berlin Heidelberg 01-06-2022 Springer Nature B.V
Subjects:	Adducts Antagonism Anticancer properties Apoptosis Bioassays Breast cancer Cancer Cancer Research Cell death Cell survival Crosslinking DNA Adducts DNA damage DNA topoisomerase (ATP-hydrolysing) DNA Topoisomerases, Type II - metabolism Flow cytometry Formaldehyde Formaldehyde - pharmacology Humans In vitro methods and tests Isoquinolines Kinases Lesions Lymphoma Medicine Medicine & Public Health Neoplasms Non-Hodgkin's lymphoma Oncology Original Article Pharmacology/Toxicology Prodrugs Prodrugs - pharmacology Releasing Scintillation counters Synergism DNA adduct Mechanism of action Formaldehyde Topoisomerase II Pixantrone
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