Curcumin protects against aging-related stress and dysfunction through autophagy activation in rat brain

Background Curcumin ( Curcuma longa ) is a well-known medicinal plant that induces autophagy in various model species, helping maintain cellular homeostasis. Its role as a caloric restriction mimetic (CRM) is being investigated. This study explores the potential of curcumin (CUR), as a CRM, to provi...

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Bibliographic Details
Published in:	Molecular biology reports Vol. 51; no. 1; p. 694
Main Authors:	Singh, Akanksha, Yadawa, Arun Kumar, Rizvi, Syed Ibrahim
Format:	Journal Article
Language:	English
Published:	Dordrecht Springer Netherlands 01-12-2024 Springer Nature B.V
Subjects:	Aging Aging - drug effects Animal Anatomy Animal Biochemistry Animals Antioxidants Antioxidants - pharmacology Autophagy Autophagy - drug effects Beclin-1 - genetics Beclin-1 - metabolism Biomedical and Life Sciences Brain - drug effects Brain - metabolism Brain - pathology Curcumin Curcumin - pharmacology Dietary restrictions Electron transport chain Galactose Galactose - pharmacology Gene expression Genes Histology Homeostasis Life Sciences Male Medicinal plants Mitochondria - drug effects Mitochondria - metabolism Morphology Neuroprotection Neuroprotective Agents - pharmacology Original Article Oxidative stress Oxidative Stress - drug effects Polymerase chain reaction Rats RNA-directed DNA polymerase Senescence Sirtuin 1 - genetics Sirtuin 1 - metabolism Tumor necrosis factor-α Aging Neuroprotection Curcumin D-galactose Autophagy Caloric restriction mimetics
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