Photoprotective activities of Capsosiphon fulvescens in UVB‐induced SKH‐1 mice and human keratinocytes

• Published in: Journal of food science Vol. 89; no. 8; pp. 5150 - 5163
• Main Authors: Seo, Jiwon, Jeong, Chanhyeok, Choi, Won Jo, Park, Jung Han Yoon, Lee, Chang Hyung, Lee, Ki Won
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01-08-2024
• Subjects: Aging; Aging (artificial); Algae; Animal models; Aquatic plants; Bioactive compounds; Capsosiphon; Capsosiphon fulvescens; Cell culture; Collagen; Dermis; Dietary fiber; Disorders; Drug delivery; Drug development; Drugs; Epidermis; Erythema; Fibers; Functional foods & nutraceuticals; Hydration; JNK protein; Keratinocytes; MAP kinase; MMP‐1; Pharmaceuticals; Pharmacology; photoaging; skin; Skin diseases; Ultraviolet radiation; UVB; Vitamins; UVB; skin; Capsosiphon fulvescens; MMP‐1; photoaging
• ISSN: 0022-1147; 1750-3841; 1750-3841
• DOI: 10.1111/1750-3841.17246

Capsosiphon fulvescens (CF) is a green alga widely consumed in East Asian countries, particularly in Korea. It has a rich composition of vitamins, minerals, dietary fibers, and bioactive compounds, which contribute to its multiple therapeutic properties. Its application ranges from acting as an antioxidant and anti‐inflammatory agent to supporting the skin system. Despite these benefits of CF, the effects and mechanisms of action related to photoaging of the skin have not yet been elucidated. To investigate the photoprotective effects of CF against photoaging, both animal (SKH‐1 mouse) and cell models (HaCaT cell line) were used in this study. As a result, administering the CF extract over a period of 10 weeks, which included times of Ultraviolet B (UVB) exposure, significantly reduced erythema and various UVB‐induced skin changes, such as wrinkle formation, and the thickening of the epidermis and dermis, as well as alterations in the length and depth of wrinkles. Furthermore, our investigation into CF extract's antiwrinkle properties revealed its efficacy in enhancing skin hydration and collagen content, counteracting the collagen depletion and moisture loss induced by UVB radiation. Also, the fact that the levels of p‐ERK, p‐p38, and p‐JNK proteins went down shows that the CF extract might have a controlling effect on the MAPK signaling pathways. Our findings suggest that CF holds significant potential for preventing photoaging, providing a foundation for the development of functional foods or botanical drugs targeting skin aging and related skin disorders.
Practical Application
This research proved that Capsosiphon fulvescen, a green alga widely consumed in East Asian countries, provides photoprotective activities against UV‐induced skin aging. Therefore, Capsosiphon fulvescen can be utilized as functional foods or botanical drugs targeting skin aging and related skin disorders.