Experimental model of double wounds on the rats back , in order to study the skin cicatrization process on rat treated with cellulose coat

To the present study were used males rats (Rattus Norvegicus, var. Albinus, Rodentia Mammalia) EPM-1 Wistar, which came from Biotério Central da UNIFESP-EPM. Each animal was submitted to two wound of circular shape, made with a "punch", with superficial cuts of 2 cm diameter; located on me...

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Bibliographic Details
Published in:Acta cirúrgica brasileira Vol. 18; no. spe; pp. 65 - 68
Main Authors: Cabral, Lecy Marcondes, Ferreira, Lydia Masako, Simões, Manuel de Jesus, Mora, Oswaldo Alves
Format: Journal Article
Language:English
Published: Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia 2003
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Summary:To the present study were used males rats (Rattus Norvegicus, var. Albinus, Rodentia Mammalia) EPM-1 Wistar, which came from Biotério Central da UNIFESP-EPM. Each animal was submitted to two wound of circular shape, made with a "punch", with superficial cuts of 2 cm diameter; located on medium line of dorsal region. In the present study, one wound was re-covered with the cellulose coat and the other serves as a control. This experimental form, makes it possible to us realize different studies such as macroscopic aspects of the wounds as well morphometric and morphological parameters analysis. Foram utilizados para o presente estudo, ratos machos (Rattus Norvegicus, var. Albinus, Rodentia Mammalia), da linhagem EPM-1 Wistar, oriundos do Biotério Central da UNIFESP-EPM.Cada animal foi submetido a duas lesões de formato circular, realizadas através de um "punch", com superfície de corte de dois centímetros de diâmetro; localizadas na linha média da região dorsal. No presente estudo uma das lesões foi recoberta com a película de celulose e a outra servindo de controle. Esta forma de modelo experimental, nos possibilita realizarmos estudos quanto ao aspecto macroscópico das lesões (contratura e fechamento das feridas), bem como a análise de parâmetros morfométricos e morfológicos, dentre outros.
ISSN:0102-8650
0102-8650
DOI:10.1590/S0102-86502003001100010