Experimental model of double wounds on the rats back , in order to study the skin cicatrization process on rat treated with cellulose coat
To the present study were used males rats (Rattus Norvegicus, var. Albinus, Rodentia Mammalia) EPM-1 Wistar, which came from Biotério Central da UNIFESP-EPM. Each animal was submitted to two wound of circular shape, made with a "punch", with superficial cuts of 2 cm diameter; located on me...
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Published in: | Acta cirúrgica brasileira Vol. 18; no. spe; pp. 65 - 68 |
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Main Authors: | , , , |
Format: | Journal Article |
Language: | English |
Published: |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
2003
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Subjects: | |
Online Access: | Get full text |
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Summary: | To the present study were used males rats (Rattus Norvegicus, var. Albinus, Rodentia Mammalia) EPM-1 Wistar, which came from Biotério Central da UNIFESP-EPM. Each animal was submitted to two wound of circular shape, made with a "punch", with superficial cuts of 2 cm diameter; located on medium line of dorsal region. In the present study, one wound was re-covered with the cellulose coat and the other serves as a control. This experimental form, makes it possible to us realize different studies such as macroscopic aspects of the wounds as well morphometric and morphological parameters analysis.
Foram utilizados para o presente estudo, ratos machos (Rattus Norvegicus, var. Albinus, Rodentia Mammalia), da linhagem EPM-1 Wistar, oriundos do Biotério Central da UNIFESP-EPM.Cada animal foi submetido a duas lesões de formato circular, realizadas através de um "punch", com superfície de corte de dois centímetros de diâmetro; localizadas na linha média da região dorsal. No presente estudo uma das lesões foi recoberta com a película de celulose e a outra servindo de controle. Esta forma de modelo experimental, nos possibilita realizarmos estudos quanto ao aspecto macroscópico das lesões (contratura e fechamento das feridas), bem como a análise de parâmetros morfométricos e morfológicos, dentre outros. |
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ISSN: | 0102-8650 0102-8650 |
DOI: | 10.1590/S0102-86502003001100010 |