Pd-catalyzed atom-efficient cross-coupling of triarylbismuth reagents with protecting group-free iodophenylmethanols: Synthesis of biarylmethanols

• Published in: Tetrahedron letters Vol. 61; no. 13; p. 151676
• Main Authors: Rao, Maddali L.N., Meka, Suresh
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 26-03-2020
• Subjects: Biarylmethanols; Iodophenylmethanols; Pd-catalysis; Triarylbismuth reagents; Pd-catalysis; Triarylbismuth reagents; Iodophenylmethanols; Biarylmethanols
• ISSN: 0040-4039; 1873-3581
• DOI: 10.1016/j.tetlet.2020.151676

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•An efficient atom-efficient synthesis of functionalized biarylmethanols.•Pd-catalyzed cross-couplings using iodophenylmethanols.•Atom-economic triarylbismuth reagents.•Protecting group-free couplings and synthesis.
An atom-efficient procedure for the synthesis of functionalized biarylmethanols via the Pd-catalyzed cross-coupling reactions of differently functionalized iodophenylmethanols and triarylbismuth reagents is described. This protecting group-free direct couplings of 2-, 3- or 4-iodophenylmethanols with triarylbismuth reagents afforded biarylmethanols in good to high yields.