Anthelmintic effect of extracts of Terminalia avicennioides against experimental nippostrongylosis in rats

• Published in: Journal of herbs, spices & medicinal plants Vol. 11; no. 3; pp. 117 - 126
• Main Authors: Suleiman, M.M, Mamman, M, Aliu, Y.O, Ajanusi, J.O, Abubakar, M.S
• Format: Journal Article
• Language: English
• Published: Binghamton, NY Taylor & Francis Group 03-11-2005; Haworth Press
• Subjects: animal disease models; animal parasitic nematodes; anthelmintics; Biological and medical sciences; dose response; Gastrointestinal parasites; General pharmacology; helminthiasis; Medical sciences; medicinal plant; medicinal plants; medicinal properties; nematode infections; Nigeria; nippostrongylosis; Nippostrongylus brasiliensis; oral administration; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; plant extracts; rats; Terminalia; Terminalia avicennioides; Nigeria; West Africa; Sub-Saharan Africa; Africa; Anthelmintic; Rat; Tropical zone; Rodentia; Parasite; Parasitosis; Gastrointestinal; Helminthiasis; Nippostrongylus brasiliensis; Medicinal plant; Infection; Gastrointestinal parasites; Vertebrata; Mammalia; Combretaceae; Dicotyledones; Angiospermae; Helmintha; Nemathelminthia; Spermatophyta; Invertebrata; Nigeria; Nematoda
• ISSN: 1049-6475; 1540-3580
• DOI: 10.1300/J044v11n03_11

Extract of Terminalia avicennioides root were evaluated for anthelmintic activity in experimental nippostrongylosis of rats. The extracts, obtained by solvent partitioning of a crude methanol extract of T. avicennioides, were given orally for three days to rats purposely infected with Nippostrongylus brasiliensis orally. Anthelmintic activity was assessed by comparing the number of worms recovered from treated rats with those recovered from infected rats not treated with T. avicennioides extract. The butanol, but not aqueous methanol, chloroform or petroleum ether extracts, produced a significant (P > 0.05), dose dependent deparasitization.