Sampling and monitoring in bioprocessing using microtechniques

Sampling and monitoring in bioprocessing using microtechniques

In this review we describe aspects of interactions between bioreactors and analytical systems including microsystems. Principles of bioprocess monitoring are summarized, before we focus on the miniaturization of sampling systems guaranteeing bioprocess sterility and providing analytical systems with...

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Bibliographic Details
Published in:Reviews in molecular biotechnology Vol. 82; no. 2; pp. 123 - 135
Main Authors: Gastrock, G., Lemke, K., Metze, J.
Format: Journal Article
Language:English
Published: Elsevier B.V 01-12-2001
Subjects:
Bioprocess
Bioreactor
Dielectrophoresis
Filtration
Microsystem
Sampling system
Bioreactor
Filtration
Dielectrophoresis
Microsystem
Sampling system
Bioprocess
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Description
Summary:In this review we describe aspects of interactions between bioreactors and analytical systems including microsystems. Principles of bioprocess monitoring are summarized, before we focus on the miniaturization of sampling systems guaranteeing bioprocess sterility and providing analytical systems with a liquid sample. The application of negative dielectrophoresis as a new principle for cell retention in a sampling system is described followed by theoretical aspects and results. Properties of micromachined silicon membranes as filters for sampling systems and for biosensor protection are discussed.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-3
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ISSN:1389-0352
DOI:10.1016/S1389-0352(01)00034-4