(27) A. niger protein “EstA”, perhaps a new electrotactin, defines a new class of fungal esterases within the α/β hydrolase fold superfamily

• Published in: Chemico-biological interactions Vol. 157; pp. 395 - 396
• Main Authors: Bourne, Yves, Hasper, Alinda A., Chahinian, Henri, Renault, Ludovic, Juin, Marianick, de Graaff, Leo H., Marchot, Pascale
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 15-12-2005; Elsevier [1969-....]
• Subjects: Aspergillus niger - enzymology; Carboxylic Ester Hydrolases - chemistry; Carboxylic Ester Hydrolases - classification; Carboxylic Ester Hydrolases - metabolism; Chimera template; Electrotactin; Life Sciences; Models, Molecular; Phylogeny; Protein Folding; Protein Structure, Tertiary; Structural biology; α/β-hydrolase; Electrotactin; α/β-hydrolase; Chimera template; Structural biology
• ISSN: 0009-2797; 1872-7786
• DOI: 10.1016/j.cbi.2005.10.072

Protein EstA from
Aspergillus niger was characterized through a multifaced approach involving molecular biology, bioinformatics, biophysical, biochemical and enzymatical analyses. EstA was identified as the lead member, within the superfamily of proteins with an α/β-hydrolase fold, of a new class of fungal esterases that also contains predicted homologs from other fungus species of known broad host-range pathogenicity.