Functional P2Y2 nucleotide receptors mediate uridine 5'-triphosphate-induced intimal hyperplasia in collared rabbit carotid arteries

Extracellular uridine 5'-triphosphate (UTP) induces mitogenic activation of smooth muscle cells (SMCs) through binding to P2Y2 nucleotide receptors. P2Y2 receptor mRNA is upregulated in intimal lesions of rat aorta, but it is unclear how this G-protein-coupled receptor contributes to developmen...

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Bibliographic Details
Published in:	Circulation (New York, N.Y.) Vol. 106; no. 21; pp. 2720 - 2726
Main Authors:	SEYE, Cheikh I, QIONGMAN KONG, ERB, Laurie, GARRAD, Richard C, KRUGH, Brent, MEIFANG WANG, TURNER, John T, STUREK, Michael, GONZALEZ, Fernando A, WEISMAN, Gary A
Format:	Journal Article
Language:	English
Published:	Hagerstown, MD Lippincott Williams & Wilkins 19-11-2002
Subjects:	Adenosine Triphosphate - pharmacology Animals Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Calcium - metabolism Cardiology. Vascular system Carotid Arteries - drug effects Carotid Arteries - metabolism Carotid Arteries - pathology Carotid Stenosis - chemically induced Carotid Stenosis - metabolism Carotid Stenosis - pathology Cell Division - drug effects Cells, Cultured Disease Models, Animal Drug Administration Routes Fluorescent Dyes Hyperplasia - chemically induced Hyperplasia - metabolism Hyperplasia - pathology Immunoblotting Inflammation - chemically induced Inflammation - pathology Macrophages - pathology Medical sciences Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - metabolism Osteopontin Rabbits Receptors, Purinergic P2 - genetics Receptors, Purinergic P2 - metabolism Receptors, Purinergic P2Y2 RNA - metabolism Sialoglycoproteins - biosynthesis Tunica Intima - drug effects Tunica Intima - metabolism Tunica Intima - pathology Up-Regulation Uridine Triphosphate Cell culture restenosis Calcium Rat receptors Pathogenesis Hyperplasia nucleotide Rodentia Cardiovascular disease Triphosphates carotid arteries Extracellular Vascular disease Vertebrata Mammalia P2Y2 purinergic receptor Animal Carotid Atherosclerosis Intima Uridine Pyrimidine nucleoside
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