Effect of gastrointestinal hormone infusions of lower oesophageal competence of rhesus monkeys

• Published in: British journal of surgery Vol. 65; no. 7; p. 499
• Main Authors: Moosa, A R, Hall, A W, Hughes, R G, Moraldi, A, Moosa, D E, Skinner, D B
• Format: Journal Article
• Language: English
• Published: England 01-07-1978
• Subjects: Animals; Cholecystokinin - pharmacology; Esophagogastric Junction - drug effects; Esophagogastric Junction - physiology; Esophagogastric Junction - physiopathology; Esophagus - surgery; Gastrectomy; Gastroesophageal Reflux - physiopathology; Glucagon - pharmacology; Haplorhini; Macaca mulatta; Male; Pressure; Secretin - pharmacology; Time Factors
• ISSN: 0007-1323
• DOI: 10.1002/bjs.1800650716

The lower oesophageal high pressure zone (HPZ) was studied in 5 non-refluxing and 3 refluxing Rhesus monkeys. The changes in HPZ and reflux status in response to infusion of various doses of secretin, cholecystokinin and glucagon were measured in all animals, and, in the 5 non-refluxing monkeys, after oesophagogastrectomy with replacement of the lower oesophagus by a stomach tube. All three hormones consistently produced a transient decrease in the HPZ pressure. The only change in response following oesophagagastrectomy and gastric tube replacement was a significant delay in the response to each hormone. Neither hormone infusion nor operation altered gastro-oesophageal reflux status. It appears that lower oesophageal competence in primates is more dependent on the presence of narrow, muscular, intra-abdominal tube than on a specialized segment of the lower oesophagus.