No influence of number of donor CFU-GM on granulocyte recovery in bone marrow transplantation for acute leukemia

• Published in: Blut Vol. 50; no. 2; pp. 89 - 94
• Main Authors: Torres, A, Alonso, M C, Gomez-Villagran, J L, Manzanares, M R, Martinez, F, Gomez, P, Garcia, J M, Andres, P, Gomez, C, Torre, M A
• Format: Journal Article
• Language: English
• Published: Germany 01-02-1985
• Subjects: Acute Disease; Adolescent; Adult; Bone Marrow Transplantation; Child; Child, Preschool; Colony-Forming Units Assay; Female; Granulocytes - transplantation; Herpes Simplex - complications; Humans; Leukemia - complications; Leukemia - therapy; Macrophages - transplantation; Male; Stem Cell Transplantation
• ISSN: 0006-5242; 1432-0584
• DOI: 10.1007/BF00321171

The possible interrelation between infused bone marrow CFU-GM and peripheral granulocyte recovery was studied in 16 patients transplanted for acute leukemia. The influence of several clinical events that could modify the graft fate were also analysed. Our results show that: 1) There was no correlation between the number of infused nucleated cells and granulocyte recovery. 2) There was no correlation between the number of infused CFU-GM and granulocyte regeneration. 3) There were significant differences between the day of engraftment in patients with clinically documented HSV infection compared to patients without infection.