Single-pot modus operandi for 2-amino-4H-chromenes synthesis utilizing amine functionalized graphene oxide decorated with zirconium oxide

• Published in: Molecular catalysis Vol. 550; p. 113591
• Main Authors: Trivedi, Komal, Kane, Sanjeev R., Goutam, U.K., Srivastava, Himanshu, Modi, Chetan K.
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01-11-2023
• Subjects: 2-amino-4H-chromenes; Graphene oxide; Multicomponent reactions; Zirconium oxide; Graphene oxide; 2-amino-4H-chromenes; Zirconium oxide; Multicomponent reactions
• ISSN: 2468-8231; 2468-8231
• DOI: 10.1016/j.mcat.2023.113591

•ZrO2-f-ED-GO catalyst was developed to synthesize 2-amino-4H-chromenes.•The method works in mild reaction conditions along with simple set-up.•The catalyst shows admirable recyclability of four times without deterioration in its function.
A lucid yet efficient protocol was developed for the multicomponent synthesis of 2-amino-3-cyano-7-hydroxy-4H-chromenes in one-pot using novel zirconium oxide grafted ethylene diamine functionalized graphene oxide (ZrO2-f-ED-GO) as a heterogeneous catalyst. The synthesized catalyst was validated with the aid of characterization methods, namely, powder X-ray diffraction (XRD), HRTEM, FTIR, XPS, FE-SEM, EDX, TGA, N2 adsorption-desorption isotherms, and Raman analysis. ZrO2-f-ED-GO was synthesized for the first time as per our knowledge and it worked as a potential candidate as a heterogeneous catalyst giving higher yields (up to 95 %) of the desired product even with less quantity of it. Considering very low weight % of Zr loading, the process becomes economically viable. In addition, the protocol is suitable for mild conditions with simple set-up and demonstrates excellent reusability up to four times without impairment of function.
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