Effect of freeze-dried bone and a dextran agglutinant on the healing of defects in the rat mandible

• Published in: The Journal of oral implantology Vol. 25; no. 3; pp. 203 - 206
• Main Authors: Luz, J G, Santiago, J L, Jorge, R S, de Araújo, V C
• Format: Journal Article
• Language: English
• Published: United States 1999
• Subjects: Animals; Anticoagulants - pharmacology; Bone Resorption; Bone Transplantation - methods; Dentistry; Dextrans - pharmacology; Foreign-Body Reaction - chemically induced; Freeze Drying; Mandible - physiopathology; Rats; Wound Healing - drug effects
• ISSN: 0160-6972; 1548-1336
• DOI: 10.1563/1548-1336(1999)025<0203:EOFDBA>2.3.CO;2

The effects of inorganic, freeze-dried bone, alone or mixed with a dextran agglutinant, on the repair of experimentally created critical-size bone defects were evaluated in the rat mandible. Histological data demonstrated a progressive resorption of the freeze-dried bone particles, without osseous proliferation into the defect, and a posterior foreign-body reaction. These results indicate that the freeze-dried bone did not induce bony healing in the critical-size defect and that the addition of dextran agglutinant did not change the tissue response. Dextran may have other applications as a biocompatible, resorbable agglutinant.