The synergic and addictive activity of biogenic silver nanoparticle (Bio-AgNP) associated with meropenem against carbapenem-resistant Acinetobacter baumannii
Antibiotic management of infections caused by Acinetobacter baumannii often fails due to antibiotic resistance (especially to carbapenems) and biofilm-forming strains. Thus, the objective here was to evaluate in vitro the antibacterial and antibiofilm activity of biogenic silver nanoparticle (Bio-Ag...
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| Published in: | Journal of applied microbiology Vol. 135; no. 3 |
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| Main Authors: | , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
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01-03-2024
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| Abstract | Antibiotic management of infections caused by Acinetobacter baumannii often fails due to antibiotic resistance (especially to carbapenems) and biofilm-forming strains. Thus, the objective here was to evaluate in vitro the antibacterial and antibiofilm activity of biogenic silver nanoparticle (Bio-AgNP) combined with meropenem, against multidrug-resistant (MDR) isolates of A. baumannii.
In this study, A. baumannii ATCC® 19606™ and four carbapenem-resistant A. baumannii (Ab) strains were used. The antibacterial activity of Bio-AgNP and meropenem was evaluated through broth microdilution. The effect of the Bio-AgNP association with meropenem was determined by the checkboard method. Also, the time-kill assay and the integrity of the bacterial cell membrane were evaluated. Furthermore, the antibiofilm activity of Bio-AgNP and meropenem alone and in combination was determined.
Bio-AgNP has antibacterial activity with MIC and MBC ranging from 0.46 to 1.87 µg/mL. The combination of Bio-AgNP and meropenem showed a synergistic and additive effect against Ab strains and Bio-AgNP was able to reduce from 4 to 8-fold the MIC of meropenem. Considering the time-kill of the cell, meropenem and Bio-AgNP when used in combination, reduced bacterial load to undetectable levels within 10 min to 24 h after treatment. Protein leakage was observed in all treatments evaluated. When combined, meropenem/Bio-AgNP presents biofilm inhibition for Ab2 isolate and ATCC® 19606™, with 21% and 19%, and disrupt the biofilm from 22% to 50%, respectively. The increase in non-viable cells in the biofilm can be observed after treatment with Bio-AgNP and meropenem in carbapenem-resistant A. baumannii strains.
The combination of Bio-AgNP with meropenem can be a therapeutic option in the treatment of infections caused by carbapenem-resistant A. baumannii. |
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| AbstractList | Antibiotic management of infections caused by Acinetobacter baumannii often fails due to antibiotic resistance (especially to carbapenems) and biofilm-forming strains. Thus, the objective here was to evaluate in vitro the antibacterial and antibiofilm activity of biogenic silver nanoparticle (Bio-AgNP) combined with meropenem, against multidrug-resistant (MDR) isolates of A. baumannii.
In this study, A. baumannii ATCC® 19606™ and four carbapenem-resistant A. baumannii (Ab) strains were used. The antibacterial activity of Bio-AgNP and meropenem was evaluated through broth microdilution. The effect of the Bio-AgNP association with meropenem was determined by the checkboard method. Also, the time-kill assay and the integrity of the bacterial cell membrane were evaluated. Furthermore, the antibiofilm activity of Bio-AgNP and meropenem alone and in combination was determined.
Bio-AgNP has antibacterial activity with MIC and MBC ranging from 0.46 to 1.87 µg/mL. The combination of Bio-AgNP and meropenem showed a synergistic and additive effect against Ab strains and Bio-AgNP was able to reduce from 4 to 8-fold the MIC of meropenem. Considering the time-kill of the cell, meropenem and Bio-AgNP when used in combination, reduced bacterial load to undetectable levels within 10 min to 24 h after treatment. Protein leakage was observed in all treatments evaluated. When combined, meropenem/Bio-AgNP presents biofilm inhibition for Ab2 isolate and ATCC® 19606™, with 21% and 19%, and disrupt the biofilm from 22% to 50%, respectively. The increase in non-viable cells in the biofilm can be observed after treatment with Bio-AgNP and meropenem in carbapenem-resistant A. baumannii strains.
The combination of Bio-AgNP with meropenem can be a therapeutic option in the treatment of infections caused by carbapenem-resistant A. baumannii. AIMSAntibiotic management of infections caused by Acinetobacter baumannii often fails due to antibiotic resistance (especially to carbapenems) and biofilm-forming strains. Thus, the objective here was to evaluate in vitro the antibacterial and antibiofilm activity of biogenic silver nanoparticle (Bio-AgNP) combined with meropenem, against multidrug-resistant isolates of A. baumannii.METHODS AND RESULTSIn this study, A. baumannii ATCC® 19606™ and four carbapenem-resistant A. baumannii (Ab) strains were used. The antibacterial activity of Bio-AgNP and meropenem was evaluated through broth microdilution. The effect of the Bio-AgNP association with meropenem was determined by the checkboard method. Also, the time-kill assay and the integrity of the bacterial cell membrane were evaluated. Furthermore, the antibiofilm activity of Bio-AgNP and meropenem alone and in combination was determined. Bio-AgNP has antibacterial activity with minimum inhibitory concentration (MIC) and minimum bactericidal concentration ranging from 0.46 to 1.87 μg ml-1. The combination of Bio-AgNP and meropenem showed a synergistic and additive effect against Ab strains, and Bio-AgNP was able to reduce the MIC of meropenem from 4- to 8-fold. Considering the time-kill of the cell, meropenem and Bio-AgNP when used in combination reduced bacterial load to undetectable levels within 10 min to 24 h after treatment. Protein leakage was observed in all treatments evaluated. When combined, meropenem/Bio-AgNP presents biofilm inhibition for Ab2 isolate and ATCC® 19606™, with 21% and 19%, and disrupts the biofilm from 22% to 50%, respectively. The increase in nonviable cells in the biofilm can be observed after treatment with Bio-AgNP and meropenem in carbapenem-resistant A. baumannii strains.CONCLUSIONSThe combination of Bio-AgNP with meropenem can be a therapeutic option in the treatment of infections caused by carbapenem-resistant A. baumannii. |
| Author | Panagio, Luciano Aparecido Allend, Suzane Olachea Oliveira, Thaís Larré Cunha, Kamila Furtado Reis, Guilherme Fonseca Nakazaro, Gerson Albernaz, Déborah Trota Faria Hartwig, Daiane Drawanz de Oliveira Garcia, Marcelle Neto, Amilton Clair Pinto Seixas |
| Author_xml | – sequence: 1 givenname: Suzane Olachea orcidid: 0000-0003-2610-0117 surname: Allend fullname: Allend, Suzane Olachea organization: Department of Microbiology and Parasitology, Institute of Biology, Federal University of Pelotas, CEP: 96010-900, Pelotas, RS, Brazil – sequence: 2 givenname: Marcelle surname: de Oliveira Garcia fullname: de Oliveira Garcia, Marcelle organization: Department of Microbiology and Parasitology, Institute of Biology, Federal University of Pelotas, CEP: 96010-900, Pelotas, RS, Brazil – sequence: 3 givenname: Kamila Furtado surname: Cunha fullname: Cunha, Kamila Furtado organization: Department of Microbiology and Parasitology, Institute of Biology, Federal University of Pelotas, CEP: 96010-900, Pelotas, RS, Brazil – sequence: 4 givenname: Déborah Trota Faria surname: Albernaz fullname: Albernaz, Déborah Trota Faria organization: Department of Microbiology and Parasitology, Institute of Biology, Federal University of Pelotas, CEP: 96010-900, Pelotas, RS, Brazil – sequence: 5 givenname: Luciano Aparecido surname: Panagio fullname: Panagio, Luciano Aparecido organization: Department of Microbiology, State University of Londrina, CEP 86057-970, Londrina, PR, Brazil – sequence: 6 givenname: Gerson surname: Nakazaro fullname: Nakazaro, Gerson organization: Department of Microbiology, State University of Londrina, CEP 86057-970, Londrina, PR, Brazil – sequence: 7 givenname: Guilherme Fonseca surname: Reis fullname: Reis, Guilherme Fonseca organization: Department of Microbiology, State University of Londrina, CEP 86057-970, Londrina, PR, Brazil – sequence: 8 givenname: Thaís Larré surname: Oliveira fullname: Oliveira, Thaís Larré organization: Biotechnology Nucleus, Technological Development Center, Federal University of Pelotas, CEP: 96010-900, Pelotas, RS, Brazil – sequence: 9 givenname: Amilton Clair Pinto Seixas surname: Neto fullname: Neto, Amilton Clair Pinto Seixas organization: Department of Microbiology and Parasitology, Institute of Biology, Federal University of Pelotas, CEP: 96010-900, Pelotas, RS, Brazil – sequence: 10 givenname: Daiane Drawanz orcidid: 0000-0003-3604-0832 surname: Hartwig fullname: Hartwig, Daiane Drawanz organization: Department of Microbiology and Parasitology, Institute of Biology, Federal University of Pelotas, CEP: 96010-900, Pelotas, RS, Brazil |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/38383758$$D View this record in MEDLINE/PubMed |
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| Keywords | meropenem carbapenem-resistant synergy anti-biofilm |
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