Monophasic dose-response curves of betamethasone on geometric and mechanical properties of femur diaphyses in growing rats

The biomechanical repercussion of the corticoid-induced osteopenia (a severe consequence of long-term glucocorticoid therapy) was studied in cortical bone of small rodents. Growing rats receiving 12.5–3200 μg/kg/d of betamethasone (BMS) s.c. for 20 days suffered a log-dose related impairment in body...

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Bibliographic Details
Published in:	Bone (New York, N.Y.) Vol. 16; no. 1; pp. 103 - 108
Main Authors:	Ferretti, J.L., Capozza, R.F., Cointry, G.R., Delgado, C.J., Zanchetta, J.R.
Format:	Journal Article
Language:	English
Published:	New York, NY Elsevier Inc 1995 Elsevier Science
Subjects:	Animals Betamethasone Betamethasone - pharmacology Biological and medical sciences Biomechanical Phenomena Bone biomechanics Bone geometry Diaphyses - drug effects Diaphyses - growth & development Dose-Response Relationship, Drug Drug toxicity and drugs side effects treatment Femur Femur - drug effects Femur - growth & development Growth Male Medical sciences Pharmacology. Drug treatments Rat Rats Toxicity: osteoarticular system Femur Rat Bone biomechanics Bone geometry Betamethasone Growth Corticosteroid Toxicity Rodentia Diseases of the osteoarticular system Mechanical properties Bone disease Dose activity relation Biomechanics Vertebrata Chemotherapy Mammalia Animal Fluorine Organic compounds Morphometry Cortical bone Osteopenia
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