Antibiotics-Induced Depletion of Rat Microbiota Induces Changes in the Expression of Host Drug-Processing Genes and Pharmacokinetic Behaviors of CYPs Probe Drugs

The metabolism of exogenous substances is affected by the gut microbiota, and the relationship between them has become a hot topic. However, the mechanisms by which the microbiota regulates drug metabolism have not been clearly defined. This study characterizes the expression profiles of host drug-p...

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Bibliographic Details

Published in:	Drug metabolism and disposition Vol. 51; no. 4; pp. 509 - 520
Main Authors:	Yang, Haijun, Zhang, Yanjuan, Zhou, Rong, Wu, Tianyuan, Zhu, Peng, Liu, Yujie, Zhou, Jian, Xiong, Yalan, Xiong, Yanling, Zhou, Honghao, Zhang, Wei, Shu, Yan, Li, Xiong, Li, Qing
Format:	Journal Article
Language:	English
Published:	United States 01-04-2023
Subjects:	Animals Anti-Bacterial Agents Cytochrome P-450 CYP2E1 - metabolism Cytochrome P-450 Enzyme System - genetics Cytochrome P-450 Enzyme System - metabolism Mice Microbiota Rats Rats, Sprague-Dawley RNA, Messenger - metabolism
Online Access:	Get full text
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