Cerebral blood flow and cerebrovascular CO2 reactivity in stroke-age normal controls

We used the noninvasive 133-xenon inhalation technique to determine cerebral hemodynamics in 55 normal volunteers aged 18 to 88. Values for cerebral blood flow and cerebrovascular CO2 reactivity in fast-clearing tissue (flow gray) and slow-clearing tissue (flow white) were examined as functions of a...

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Bibliographic Details
Published in:	Neurology Vol. 33; no. 4; pp. 391 - 399
Main Authors:	Davis, S M, Ackerman, R H, Correia, J A, Alpert, N M, Chang, J, Buonanno, F, Kelley, R E, Rosner, B, Taveras, J M
Format:	Journal Article
Language:	English
Published:	United States 01-04-1983
Subjects:	Adolescent Adult Aged Aging Blood Pressure - drug effects Brain - blood supply Carbon Dioxide - pharmacology Cerebrovascular Circulation - drug effects Cerebrovascular Disorders - physiopathology Child Female Hematocrit Humans Male Middle Aged Pulse - drug effects Ultrasonography Vascular Resistance - drug effects
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Summary:	We used the noninvasive 133-xenon inhalation technique to determine cerebral hemodynamics in 55 normal volunteers aged 18 to 88. Values for cerebral blood flow and cerebrovascular CO2 reactivity in fast-clearing tissue (flow gray) and slow-clearing tissue (flow white) were examined as functions of age and in relation to hematocrit, blood pressure, and evidence of extracranial vascular disease. Flow gray declined linearly with age, but no corresponding change was found in flow white or in CO2 reactivity. The data suggest that the progressive fall in flow gray is due to a physiologic aging process.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0028-3878
DOI:	10.1212/wnl.33.4.391