A review of FGF18: Its expression, signaling pathways and possible functions during embryogenesis and post-natal development

FGF18 is a novel growth factor first reported in 1998. Current evidence suggests that FGF18 may play a prominent role in chondrogenesis and osteogenesis during skeletal development and growth. However, its function extends to many other biological processes. Although there remains much to be discove...

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Bibliographic Details
Published in:	Histology and histopathology Vol. 22; no. 1; pp. 97 - 105
Main Authors:	Haque, T, Nakada, S, Hamdy, R C
Format:	Journal Article
Language:	English
Published:	Spain 01-01-2007
Subjects:	Animals Bone and Bones - metabolism Bone Development Cell Differentiation Embryonic Development Fibroblast Growth Factor 2 - biosynthesis Fibroblast Growth Factor 2 - physiology Fibroblast Growth Factors - biosynthesis Fibroblast Growth Factors - physiology Gene Expression Gene Expression Regulation, Developmental Humans Mice Mice, Knockout Models, Biological Signal Transduction
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Summary:	FGF18 is a novel growth factor first reported in 1998. Current evidence suggests that FGF18 may play a prominent role in chondrogenesis and osteogenesis during skeletal development and growth. However, its function extends to many other biological processes. Although there remains much to be discovered and investigated on the functions and mechanisms of FGF18, it may play a role as a useful therapeutic target for various applications. The following review summarizes the current knowledge on FGF18 with special emphasis on its skeletal functions and highlights its potential areas for future research.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	1699-5848
DOI:	10.14670/HH-22.97