A novel and facile route for the synthesis of medetomidine as the α2-adrenoceptor agonist

We report here a novel and facile method for the synthesis of (±)-4(5)-[1-(2,3-dimethylphenyl)ethyl]-1 H -imidazole (medetomidine) in a good yield in five steps. The method involves Wittig olefination of the phenylimidazolylketones, followed by a hydrogenation. We demonstrate that the Wittig alkenyl...

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Bibliographic Details
Published in:	Journal of the Iranian Chemical Society Vol. 14; no. 8; pp. 1735 - 1739
Main Authors:	Kaboudin, Babak, Haghighat, Hamideh, Aieni, Samira, Behrouzi, Leila, Kazemi, Foad, Kato, Jun-ya, Aoyama, Hiroshi, Yokomatsu, Tsutomu
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer Berlin Heidelberg 01-08-2017 Springer Nature B.V
Subjects:	Analytical Chemistry Biochemistry Chemical synthesis Chemistry Chemistry and Materials Science Dehydration Hydrogenation Imidazole Inorganic Chemistry Methylation Organic Chemistry Original Paper Physical Chemistry Medetomidine Wittig reaction α Methanone Imidazole adrenoceptor agonist
Online Access:	Get full text
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