The effectiveness of organic vegetable oils with high biocompatibility in preventing epidural fibrosis: An experimental study

• Published in: Ideggyógyászati szemle Vol. 76; no. 11-12; p. 379
• Main Authors: Mehmet, Akgul Huseyin, Mehmet Yigit, Akgun, Tugce, Anteplioglu, Oguz, Kul
• Format: Journal Article
• Language: English
• Published: Hungary 30-11-2023
• Subjects: Animals; Epidural Space - pathology; Fibrosis; Humans; Laminectomy - adverse effects; Male; Olive Oil - pharmacology; Olive Oil - therapeutic use; Plant Oils - pharmacology; Plant Oils - therapeutic use; Rats; Rats, Wistar; Soybean Oil; olive oil; epidural fibrosis; laminectomy; Nigella sativa; soybean oil
• DOI: 10.18071/isz.76.0379
• ISSN: 0019-1442

Epidural fibrosis after all spinal surgeries is an important surgical issue. Various biological and non-biological materials have been tried to inhibit epidural fibrosis, which is deemed to be the most important cause of pain after spinal surgery. Olive oil, nigella sativa oil and soybean oil employed in oral nutrition in clinics involving liquid fatty acids, palmatic acid, linoleic acid, stearic acid and palmitoleic acid. The effectiveness of olive oil, nigella sativa oil and soybean oil on epidural fibrosis was researched on for the first time in laminectomy model..
Fifty adult male Wistar albino rats weighing between 300 and 400 grams were used in the research. A total of 5 groups were formed: sham (Group I) (n = 10), no application was created; Group II (n = 10) 1 cc saline; Group III (n = 10) 1 cc olive oil; Group IV (n = 10) 1 cc nigella sativa oil; Group V (n = 10); 1 cc soybean oil was applied topically to the epidural region after laminectomy. The total spine of the rats was dissected, histopathological and immuno­chemical measurements were conducted. Neuro-histopathological results were scored semi-quantitatively in terms of vascular modification, neuron degeneration, gliosis and bleeding criteria..
The lowest level of fibrosis and connective tissue proliferation was observed in the group where nigella sativa oil was used after the operation, followed by the group treated with olive oil and lastly with the group given soybean oil..
Nigella sativa oil and olive oil are very efficient for lowering the degree of epidural fibrosis and adhesions following laminectomy and can be employed as a simple, inexpensive and highly biocompatible material in clinical practice..