Possible role of TORCH agents in congenital malformations in Gorgan, northern Islamic Republic of Iran

This descriptive, cross-sectional study was carried out to explore the frequency of contamination with TORCH agents in neonates with congenital malformations in a referral centre in Gorgan city, Islamic Republic of Iran. Blood samples were taken from 64 neonates and their mothers over a 20-month per...

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Bibliographic Details
Published in:	Eastern Mediterranean health journal Vol. 15; no. 2; pp. 330 - 336
Main Authors:	Golalipour, M J, Khodabakhshi, B, Ghaemi, E
Format:	Journal Article
Language:	English
Published:	Egypt 01-03-2009
Subjects:	Adult Animals Antibodies, Protozoan - blood Antibodies, Viral - blood Causality Congenital Abnormalities - epidemiology Congenital Abnormalities - etiology Cross-Sectional Studies Cytomegalovirus - immunology Cytomegalovirus Infections - blood Cytomegalovirus Infections - complications Cytomegalovirus Infections - epidemiology Cytomegalovirus Infections - immunology Female Humans Immunoglobulin M - blood Infant, Newborn Iran - epidemiology Male Population Surveillance Pregnancy Pregnancy Complications, Infectious - blood Pregnancy Complications, Infectious - epidemiology Pregnancy Complications, Infectious - immunology Rubella - blood Rubella - complications Rubella - epidemiology Rubella - immunology Rubella virus - immunology Toxoplasma - immunology Toxoplasmosis, Congenital - blood Toxoplasmosis, Congenital - complications Toxoplasmosis, Congenital - epidemiology Toxoplasmosis, Congenital - immunology Iran
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Summary:	This descriptive, cross-sectional study was carried out to explore the frequency of contamination with TORCH agents in neonates with congenital malformations in a referral centre in Gorgan city, Islamic Republic of Iran. Blood samples were taken from 64 neonates and their mothers over a 20-month period in 2003-04. Serologic tests showed that 4/64 infants born with congenital malformations (6%) had positive 1 gM antibody titres for Texoplasma gondil (2 cases), rubella virus (1 case) and cytomegalovirus (1 case). 1 gM was positive in 9/63 mothers (14%), also for T. gondil (3 cases), rubella virus (3 cases) and cytomegalovirus (3 cases). No cases of herpes simplex virus type II or Treponema pallidum were found.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1020-3397 1687-1634
DOI:	10.26719/2009.15.2.330