Case Report: Mepolizumab in the treatment of idiopathic chronic eosinophilic pneumonia [version 3; peer review: 2 approved]
Idiopathic chronic eosinophilic pneumonia (ICEP) is a rare interstitial lung disease of unknown cause. It usually responds well to systemic corticosteroid therapy, but relapses are frequent. We describe two cases of 21- and 27-year-old patients, presenting with dyspnea. The diagnosis of steroid-rela...
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| Published in: | F1000 research Vol. 12; p. 337 |
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| Main Authors: | , , , , , , |
| Format: | Journal Article |
| Language: | English |
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2023
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| Abstract | Idiopathic chronic eosinophilic pneumonia (ICEP) is a rare interstitial lung disease of unknown cause. It usually responds well to systemic corticosteroid therapy, but relapses are frequent. We describe two cases of 21- and 27-year-old patients, presenting with dyspnea. The diagnosis of steroid-relapsing and steroid-dependent ICEP was made respectively. Mepolizumab was prescribed to both patients. This treatment resulted in successful long-term disease management with much fewer side effects than a traditional corticosteroid therapy. |
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| AbstractList | Idiopathic chronic eosinophilic pneumonia (ICEP) is a rare interstitial lung disease of unknown cause. It usually responds well to systemic corticosteroid therapy, but relapses are frequent. We describe two cases of 21- and 27-year-old patients, presenting with dyspnea. The diagnosis of steroid-relapsing and steroid-dependent ICEP was made respectively. Mepolizumab was prescribed to both patients. This treatment resulted in successful long-term disease management with much fewer side effects than a traditional corticosteroid therapy. |
| Author | Mhamdi, Samira Daboussi, Selsabil Essebaa, Samia Ayadi, Aida Hela, Ghedira Zied, Moetemri Aichaouia, Chiraz |
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| Cites_doi | 10.1016/j.jaip.2020.01.058 10.7573/dic.2020-5-3 10.1016/j.jaip.2018.06.017 10.1007/s00408-020-00336-3 10.1080/02770903.2018.1534966 10.18176/jiaci.0671 10.1016/j.jaip.2022.12.022 10.1016/j.jaci.2018.09.033 10.1016/j.anai.2021.02.016 10.1080/02770903.2018.1543434 |
| ContentType | Journal Article |
| Copyright | Copyright: © 2023 Daboussi S et al. Copyright: © 2023 Daboussi S et al. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
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| DOI | 10.12688/f1000research.130939.3 |
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| Keywords | Corticosteroid Treatment Idiopathic chronic eosinophilic pneumonia Mepolizumab |
| Language | English |
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| References | E Sarkis (ref2) 2018 Nov 16; 57 R Lin (ref9) 2019 Nov; 56 E Brenard (ref7) 2020 Apr 1; 198 M To (ref5) 2018 Sep; 6 A Kisling (ref3) 2020 Aug 18; 9 Q Delcros (ref4) 2022 Dec M Nasser (ref8) 2020 Jun; 8 S Khatri (ref10) 2019 May; 143 H Sato (ref1) 2021 Oct 22; 31 P Ricketti (ref6) 2021 Jun; 126 |
| References_xml | – volume: 8 start-page: 2092-2095 year: 2020 Jun ident: ref8 article-title: Lung-limited or lung-dominant variant of Eosinophilic Granulomatosis with Polyangiitis. publication-title: J Allergy Clin Immunol Pract. doi: 10.1016/j.jaip.2020.01.058 contributor: fullname: M Nasser – volume: 9 start-page: 1-7 year: 2020 Aug 18 ident: ref3 article-title: Mepolizumab: an alternative therapy for idiopathic chronic eosinophilic pneumonia with glucocorticoid intolerance. publication-title: Drugs Context. doi: 10.7573/dic.2020-5-3 contributor: fullname: A Kisling – volume: 6 start-page: 1746-1748.e1 year: 2018 Sep ident: ref5 article-title: A case of chronic eosinophilic pneumonia successfully treated with mepolizumab. publication-title: J Allergy Clin Immunol Pract. doi: 10.1016/j.jaip.2018.06.017 contributor: fullname: M To – volume: 198 start-page: 355-360 year: 2020 Apr 1 ident: ref7 article-title: Real-Life Study of Mepolizumab in Idiopathic Chronic Eosinophilic Pneumonia. publication-title: Lung. doi: 10.1007/s00408-020-00336-3 contributor: fullname: E Brenard – volume: 56 start-page: 1193-1197 year: 2019 Nov ident: ref9 article-title: Favorable response to asthma-dosed subcutaneous mepolizumab in eosinophilic pneumonia. publication-title: J Asthma. doi: 10.1080/02770903.2018.1534966 contributor: fullname: R Lin – volume: 31 start-page: 459-460 year: 2021 Oct 22 ident: ref1 article-title: Efficacy of Mepolizumab Extended Interval Dosing for 2 Asthmatic Patients With Chronic Eosinophilic Pneumonia. publication-title: J Investig Allergol Clin Immunol. doi: 10.18176/jiaci.0671 contributor: fullname: H Sato – year: 2022 Dec ident: ref4 article-title: Targeting IL-5/5R for the treatment of idiopathic chronic eosinophilic pneumonia. publication-title: J Allergy Clin Immunol Pract. doi: 10.1016/j.jaip.2022.12.022 contributor: fullname: Q Delcros – volume: 143 start-page: 1742-1751.e7 year: 2019 May ident: ref10 article-title: Assessment of the long-term safety of mepolizumab and durability of clinical response in patients with severe eosinophilic asthma. publication-title: J Allergy Clin Immunol. doi: 10.1016/j.jaci.2018.09.033 contributor: fullname: S Khatri – volume: 126 start-page: 726-727 year: 2021 Jun ident: ref6 article-title: Relapsing chronic eosinophilic pneumonia treated successfully with benralizumab. publication-title: Ann Allergy Asthma Immunol. doi: 10.1016/j.anai.2021.02.016 contributor: fullname: P Ricketti – volume: 57 start-page: 82-86 year: 2018 Nov 16 ident: ref2 article-title: Anti-interleukin (IL)-5 as a steroid-sparing agent in chronic eosinophilic pneumonia. publication-title: J Asthma. doi: 10.1080/02770903.2018.1543434 contributor: fullname: E Sarkis |
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| Title | Case Report: Mepolizumab in the treatment of idiopathic chronic eosinophilic pneumonia [version 3; peer review: 2 approved] |
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