Activity of Nonnucleoside Inhibitors of O6-methylguanine-DNA Methyltransferase Repair Enzyme in Human Cells In Vitro

The repair enzyme O 6 -methylguanine-DNA methyltransferase (MGMT) eliminates alkyl lesions that play the main anticancer role in alkylating chemotherapy. The inhibition of MGMT leads to increasing effectiveness of alkylating chemotherapy. In this study, new potential MGMT inhibitors were tested. It...

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Published in:	Cytology and genetics Vol. 57; no. 6; pp. 556 - 566
Main Authors:	Zhuvaka, K. S., Volynets, G. P., Ruban, T. P., Nidoeva, Z. M., Iatsyshyna, A. P., Macewizc, L. L., Bdzhola, V. G., Yarmoluk, S. M., Lukash, L. L.
Format:	Journal Article
Language:	English
Published:	Moscow Pleiades Publishing 01-12-2023 Springer Nature B.V
Subjects:	Biomedical and Life Sciences Biomedicine Chemotherapy Cytotoxicity DNA methyltransferase DNA repair Human Genetics Methylguanine O6-methylguanine-DNA methyltransferase Repair enzyme MGMT cell line HEp-2 new potential MGMT inhibitors alkylating agent
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Abstract	The repair enzyme O 6 -methylguanine-DNA methyltransferase (MGMT) eliminates alkyl lesions that play the main anticancer role in alkylating chemotherapy. The inhibition of MGMT leads to increasing effectiveness of alkylating chemotherapy. In this study, new potential MGMT inhibitors were tested. It was found that some compounds demonstrate low cytotoxicity and high effectiveness in human cells in vitro .
AbstractList	The repair enzyme O6-methylguanine-DNA methyltransferase (MGMT) eliminates alkyl lesions that play the main anticancer role in alkylating chemotherapy. The inhibition of MGMT leads to increasing effectiveness of alkylating chemotherapy. In this study, new potential MGMT inhibitors were tested. It was found that some compounds demonstrate low cytotoxicity and high effectiveness in human cells in vitro. The repair enzyme O 6 -methylguanine-DNA methyltransferase (MGMT) eliminates alkyl lesions that play the main anticancer role in alkylating chemotherapy. The inhibition of MGMT leads to increasing effectiveness of alkylating chemotherapy. In this study, new potential MGMT inhibitors were tested. It was found that some compounds demonstrate low cytotoxicity and high effectiveness in human cells in vitro .
Author	Macewizc, L. L. Bdzhola, V. G. Lukash, L. L. Nidoeva, Z. M. Iatsyshyna, A. P. Volynets, G. P. Yarmoluk, S. M. Zhuvaka, K. S. Ruban, T. P.
Author_xml	– sequence: 1 givenname: K. S. surname: Zhuvaka fullname: Zhuvaka, K. S. email: kateopryshko@gmail.com organization: Department of Human Genetics, Institute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine – sequence: 2 givenname: G. P. surname: Volynets fullname: Volynets, G. P. email: g.p.volynets@gmail.com organization: Department of Human Genetics, Institute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine – sequence: 3 givenname: T. P. surname: Ruban fullname: Ruban, T. P. email: tullip@ukr.net organization: Department of Human Genetics, Institute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine – sequence: 4 givenname: Z. M. surname: Nidoeva fullname: Nidoeva, Z. M. email: zarinanidoeva@gmail.com organization: Department of Human Genetics, Institute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine – sequence: 5 givenname: A. P. surname: Iatsyshyna fullname: Iatsyshyna, A. P. email: yazishinaa@yahoo.com organization: Department of Human Genetics, Institute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine – sequence: 6 givenname: L. L. surname: Macewizc fullname: Macewizc, L. L. email: macewicz71@gmail.com organization: Department of Human Genetics, Institute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine – sequence: 7 givenname: V. G. surname: Bdzhola fullname: Bdzhola, V. G. email: bdzhol@gmail.com organization: Department of Human Genetics, Institute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine – sequence: 8 givenname: S. M. surname: Yarmoluk fullname: Yarmoluk, S. M. email: serhiy.yarmoluk@gmail.com organization: Department of Human Genetics, Institute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine – sequence: 9 givenname: L. L. surname: Lukash fullname: Lukash, L. L. email: luKash.imbg@gmail.com organization: Department of Human Genetics, Institute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine
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Cites_doi	10.1016/j.etap.2019.03.012 10.1021/jm00002a018 10.1093/bmb/ldm036 10.1158/1078-0432.ccr-08-2130 10.1021/jm000961o 10.1007/s10528-018-9854-9 10.1016/j.mrgentox.2019.04.006 10.1016/j.ddtec.2004.11.007 10.1021/jm800758y 10.1093/bioinformatics/btaa774 10.1016/j.dnarep.2007.03.007 10.1002/jcc.21256 10.1021/jm00103a019 10.1016/j.bmc.2011.01.038 10.1021/jm970712f 10.3389/fonc.2019.01547 10.1021/jm9804388 10.3103/S0095452713040087 10.1021/tx200031q 10.1021/ci800202t 10.1158/1078-0432.ccr-05-2198 10.1007/s00018-010-0491-7 10.1016/s1383-5742(00)00017-x 10.1002/anie.201510203 10.1016/0027-5107(91)90196-U 10.1016/j.bbcan.2011.06.002 10.1158/0008-5472.CAN-14-2047
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Copyright	Allerton Press, Inc. 2023. ISSN 0095-4527, Cytology and Genetics, 2023, Vol. 57, No. 6, pp. 556–566. © Allerton Press, Inc., 2023, corrected publication 2023. Ukrainian Text © The Author(s), 2023, published in Tsitologiya i Genetika, 2023, Vol. 57, No. 6, pp. 48–59. Allerton Press, Inc. 2023. ISSN 0095-4527, Cytology and Genetics, 2023, Vol. 57, No. 6, pp. 556–566. © Allerton Press, Inc., 2023, corrected publication 2023. Ukrainian Text © The Author(s), 2023, published in Tsitologiya i Genetika, 2023, Vol. 57, No. 6, pp. 48–59.
Copyright_xml	– notice: Allerton Press, Inc. 2023. ISSN 0095-4527, Cytology and Genetics, 2023, Vol. 57, No. 6, pp. 556–566. © Allerton Press, Inc., 2023, corrected publication 2023. Ukrainian Text © The Author(s), 2023, published in Tsitologiya i Genetika, 2023, Vol. 57, No. 6, pp. 48–59. – notice: Allerton Press, Inc. 2023. ISSN 0095-4527, Cytology and Genetics, 2023, Vol. 57, No. 6, pp. 556–566. © Allerton Press, Inc., 2023, corrected publication 2023. Ukrainian Text © The Author(s), 2023, published in Tsitologiya i Genetika, 2023, Vol. 57, No. 6, pp. 48–59.
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Snippet	The repair enzyme O 6 -methylguanine-DNA methyltransferase (MGMT) eliminates alkyl lesions that play the main anticancer role in alkylating chemotherapy. The... The repair enzyme O6-methylguanine-DNA methyltransferase (MGMT) eliminates alkyl lesions that play the main anticancer role in alkylating chemotherapy. The...
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SubjectTerms	Biomedical and Life Sciences Biomedicine Chemotherapy Cytotoxicity DNA methyltransferase DNA repair Human Genetics Methylguanine O6-methylguanine-DNA methyltransferase
Title	Activity of Nonnucleoside Inhibitors of O6-methylguanine-DNA Methyltransferase Repair Enzyme in Human Cells In Vitro
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