Activity of Nonnucleoside Inhibitors of O6-methylguanine-DNA Methyltransferase Repair Enzyme in Human Cells In Vitro

The repair enzyme O 6 -methylguanine-DNA methyltransferase (MGMT) eliminates alkyl lesions that play the main anticancer role in alkylating chemotherapy. The inhibition of MGMT leads to increasing effectiveness of alkylating chemotherapy. In this study, new potential MGMT inhibitors were tested. It...

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Bibliographic Details
Published in:	Cytology and genetics Vol. 57; no. 6; pp. 556 - 566
Main Authors:	Zhuvaka, K. S., Volynets, G. P., Ruban, T. P., Nidoeva, Z. M., Iatsyshyna, A. P., Macewizc, L. L., Bdzhola, V. G., Yarmoluk, S. M., Lukash, L. L.
Format:	Journal Article
Language:	English
Published:	Moscow Pleiades Publishing 01-12-2023 Springer Nature B.V
Subjects:	Biomedical and Life Sciences Biomedicine Chemotherapy Cytotoxicity DNA methyltransferase DNA repair Human Genetics Methylguanine O6-methylguanine-DNA methyltransferase Repair enzyme MGMT cell line HEp-2 new potential MGMT inhibitors alkylating agent
Online Access:	Get full text
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Summary:	The repair enzyme O 6 -methylguanine-DNA methyltransferase (MGMT) eliminates alkyl lesions that play the main anticancer role in alkylating chemotherapy. The inhibition of MGMT leads to increasing effectiveness of alkylating chemotherapy. In this study, new potential MGMT inhibitors were tested. It was found that some compounds demonstrate low cytotoxicity and high effectiveness in human cells in vitro .
ISSN:	0095-4527 1934-9440
DOI:	10.3103/S0095452723060105