Pathophysiologic mechanisms linking impaired cardiovascular health and neurologic dysfunction: the year in review

• Published in: Cleveland Clinic journal of medicine Vol. 77 Suppl 3; no. 7 suppl 3; pp. S40 - S45
• Main Authors: Park, Ki E, Pepine, Carl J
• Format: Journal Article
• Language: English
• Published: United States 01-07-2010
• Subjects: Blood Platelets - metabolism; Cardiovascular Diseases - etiology; Cardiovascular Diseases - physiopathology; Depression - physiopathology; Endothelium, Vascular - cytology; Endothelium, Vascular - physiopathology; Genetic Predisposition to Disease; Humans; Hypothalamo-Hypophyseal System - physiopathology; Migraine Disorders - genetics; Myocardial Ischemia - etiology; Myocardial Ischemia - genetics; Nervous System Diseases - etiology; Nervous System Diseases - physiopathology; Pituitary-Adrenal System - physiopathology; Serotonin - adverse effects; Serotonin - genetics; Serotonin - metabolism; Serotonin Plasma Membrane Transport Proteins - genetics; Stress, Psychological - complications; Stroke - genetics
• ISSN: 0891-1150; 1939-2869
• DOI: 10.3949/ccjm.77.s3.07

The nervous system and cardiovascular system have long been known to interact. Only more recently, however, have the mechanisms driving this interaction become more clearly understood. Although many psychological disturbances, including depression and anxiety, are known to predict poor outcomes in patients with cardiovascular disease, other neurologic disturbances, such as migraine and stroke, have been connected to poor cardiovascular outcomes as well. Although these connections were traditionally thought to be due to shared risk factors, recent research has focused on pathophysiologic mechanisms underlying these interactions, including neuroendocrine dysregulation, genetic predisposition, and vascular dysfunction.