Osteoradionecrosis incidence in pre-radiation teeth extractions: A prospective study
To evaluate osteoradionecrosis (ORN) incidence in a cohort of patients undergoing tooth extraction (TE) before radiotherapy (RT) for head and neck cancers. The study protocol was approved by the Ethics Committee of Università Cattolica del Sacro Cuore (ID-2132) and registered at clinicaltrials.gov (...
Saved in:
| Published in: | Oral diseases |
|---|---|
| Main Authors: | , , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Denmark
09-04-2024
|
| Subjects: | |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | To evaluate osteoradionecrosis (ORN) incidence in a cohort of patients undergoing tooth extraction (TE) before radiotherapy (RT) for head and neck cancers.
The study protocol was approved by the Ethics Committee of Università Cattolica del Sacro Cuore (ID-2132) and registered at clinicaltrials.gov (ID: NCT04009161). TE was performed in case of signs of pericoronitis, periapical lesions, restorative impossibility, severe periodontitis. ORN was defined as exposed bone at an unhealed post-extraction socket in the absence of oncological recurrence. The RT plans were reviewed, and each post-extractive socket was contoured to calculate the received radiation dose.
In total, 156 patients with 610 TE were enrolled. The mean follow-up was 567 days. ORN was diagnosed in four patients (2.6% of patients and 0.7% of TE). Need for osteotomy and radiation dose at the extraction site were associated with ORN (OR for osteotomy: 21.9, 95% CI: 2.17-222.2, p = 0.009; OR for RT dose: 1.1, 95% CI: 1-1.15, p = 0.05).
TE appears to be a significant risk factor for ORN, particularly when osteotomy is required, and post-extraction sockets receive a high RT dosage. This study proposes a decision-making algorithm for TE and outlines a straightforward surgical protocol. |
|---|---|
| AbstractList | AIMSTo evaluate osteoradionecrosis (ORN) incidence in a cohort of patients undergoing tooth extraction (TE) before radiotherapy (RT) for head and neck cancers.METHODSThe study protocol was approved by the Ethics Committee of Università Cattolica del Sacro Cuore (ID-2132) and registered at clinicaltrials.gov (ID: NCT04009161). TE was performed in case of signs of pericoronitis, periapical lesions, restorative impossibility, severe periodontitis. ORN was defined as exposed bone at an unhealed post-extraction socket in the absence of oncological recurrence. The RT plans were reviewed, and each post-extractive socket was contoured to calculate the received radiation dose.RESULTSIn total, 156 patients with 610 TE were enrolled. The mean follow-up was 567 days. ORN was diagnosed in four patients (2.6% of patients and 0.7% of TE). Need for osteotomy and radiation dose at the extraction site were associated with ORN (OR for osteotomy: 21.9, 95% CI: 2.17-222.2, p = 0.009; OR for RT dose: 1.1, 95% CI: 1-1.15, p = 0.05).CONCLUSIONSTE appears to be a significant risk factor for ORN, particularly when osteotomy is required, and post-extraction sockets receive a high RT dosage. This study proposes a decision-making algorithm for TE and outlines a straightforward surgical protocol. To evaluate osteoradionecrosis (ORN) incidence in a cohort of patients undergoing tooth extraction (TE) before radiotherapy (RT) for head and neck cancers. The study protocol was approved by the Ethics Committee of Università Cattolica del Sacro Cuore (ID-2132) and registered at clinicaltrials.gov (ID: NCT04009161). TE was performed in case of signs of pericoronitis, periapical lesions, restorative impossibility, severe periodontitis. ORN was defined as exposed bone at an unhealed post-extraction socket in the absence of oncological recurrence. The RT plans were reviewed, and each post-extractive socket was contoured to calculate the received radiation dose. In total, 156 patients with 610 TE were enrolled. The mean follow-up was 567 days. ORN was diagnosed in four patients (2.6% of patients and 0.7% of TE). Need for osteotomy and radiation dose at the extraction site were associated with ORN (OR for osteotomy: 21.9, 95% CI: 2.17-222.2, p = 0.009; OR for RT dose: 1.1, 95% CI: 1-1.15, p = 0.05). TE appears to be a significant risk factor for ORN, particularly when osteotomy is required, and post-extraction sockets receive a high RT dosage. This study proposes a decision-making algorithm for TE and outlines a straightforward surgical protocol. |
| Author | Cordaro, M Tagliaferri, L Lajolo, C Mele, D Massaccesi, M Pastore, F Specchia, M L Cassano, A Rupe, C Galli, J Gioco, G Micciché, F |
| Author_xml | – sequence: 1 givenname: C orcidid: 0000-0001-9928-4100 surname: Rupe fullname: Rupe, C organization: Head and Neck Department, Fondazione Policlinico Universitario A. Gemelli-IRCCS, School of Dentistry, Università Cattolica del Sacro Cuore, Rome, Italy – sequence: 2 givenname: G orcidid: 0000-0002-8637-2029 surname: Gioco fullname: Gioco, G organization: Head and Neck Department, Fondazione Policlinico Universitario A. Gemelli-IRCCS, School of Dentistry, Università Cattolica del Sacro Cuore, Rome, Italy – sequence: 3 givenname: M surname: Massaccesi fullname: Massaccesi, M organization: Department of Radiation Oncology, Fondazione Policlinico Universitario A. Gemelli-IRCCS, Institute of Radiology, Università Cattolica del Sacro Cuore, Rome, Italy – sequence: 4 givenname: L surname: Tagliaferri fullname: Tagliaferri, L organization: Department of Radiation Oncology, Fondazione Policlinico Universitario A. Gemelli-IRCCS, Institute of Radiology, Università Cattolica del Sacro Cuore, Rome, Italy – sequence: 5 givenname: F surname: Pastore fullname: Pastore, F organization: Department of Radiation Oncology, Fondazione Policlinico Universitario A. Gemelli-IRCCS, Institute of Radiology, Università Cattolica del Sacro Cuore, Rome, Italy – sequence: 6 givenname: F surname: Micciché fullname: Micciché, F organization: Oncologic Radiotherapy, Ospedale Isola Tiberina Gemelli Isola, Rome, Italy – sequence: 7 givenname: J surname: Galli fullname: Galli, J organization: Head and Neck Department, Fondazione Policlinico Universitario A. Gemelli-IRCCS, Institute of Otolaryngology, Università Cattolica del Sacro Cuore, Rome, Italy – sequence: 8 givenname: D surname: Mele fullname: Mele, D organization: Head and Neck Department, Fondazione Policlinico Universitario A. Gemelli-IRCCS, Institute of Otolaryngology, Università Cattolica del Sacro Cuore, Rome, Italy – sequence: 9 givenname: M L surname: Specchia fullname: Specchia, M L organization: Department of Life Sciences and Public Health, Fondazione Policlinico Universitario A. Gemelli-IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy – sequence: 10 givenname: A surname: Cassano fullname: Cassano, A organization: Department of Medical Oncology, Fondazione Policlinico Universitario A. Gemelli-IRCCS, Institute of Radiology, Università Cattolica del Sacro Cuore, Rome, Italy – sequence: 11 givenname: M surname: Cordaro fullname: Cordaro, M organization: Head and Neck Department, Fondazione Policlinico Universitario A. Gemelli-IRCCS, School of Dentistry, Università Cattolica del Sacro Cuore, Rome, Italy – sequence: 12 givenname: C surname: Lajolo fullname: Lajolo, C organization: Head and Neck Department, Fondazione Policlinico Universitario A. Gemelli-IRCCS, School of Dentistry, Università Cattolica del Sacro Cuore, Rome, Italy |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/38591808$$D View this record in MEDLINE/PubMed |
| BookMark | eNo9kMlOwzAQhi1UREvhwAugHOGQYsdLEm5VxSZV6qVI3CwvY2HUJiV2EH17HFqYy2yffs3852jUtA0gdEXwjKS4a62fEVYzcoImRGCS46rgo1RTznJe0LcxOg_hA2NS1rQ4Q2Na8ZpUuJqg9SpEaDtlfZI0XRt8yHxjvIXGQKqyXQf5sFYxEVkEiO8ZfMdOmWEQ7rN5Qtqwg9R_QRZib_cX6NSpTYDLY56i18eH9eI5X66eXhbzZW4KxmOuAVNrS6uUxVobrbUtHXfCkVKA4Zxqw0DUzDgHRcl5ZTh1haDCcauV4HSKbg666YLPHkKUWx8MbDaqgbYPkmLKcckErRN6e0CHH0MHTu46v1XdXhIsBxNlMlH-mpjY66Nsr7dg_8k_1-gP8IlxZA |
| Cites_doi | 10.1016/j.ijom.2019.01.001 10.1034/j.1600-051X.2003.00366.x 10.1002/lary.28066 10.1902/jop.2007.070210 10.1002/hed.23995 10.1016/j.oraloncology.2021.105604 10.1002/hed.23949 10.1097/jnr.0000000000000401 10.3390/dj10070121 10.1016/0196-0709(90)90084-9 10.4103/0975-5950.183870 10.1007/s10006-019-00783-0 10.1016/j.radonc.2004.08.021 10.1177/0194599810396290 10.3390/cancers14194746 10.1016/0278-2391(83)90294-X 10.1016/j.joms.2003.08.009 10.1054/ijom.2002.0332 10.1111/jcpe.13286 10.1016/j.ijom.2010.10.005 10.3322/caac.21660 10.1186/s12903-023-03050-7 10.1002/hed.26611 10.1007/s00405-023-07885-2 10.1016/j.mayocp.2015.12.017 10.17219/dmp/144596 10.1111/j.1601-0825.2006.01351.x 10.1016/j.joen.2019.12.005 10.1016/j.joms.2022.04.009 10.1016/j.radonc.2022.05.031 10.1007/s00066-015-0875-6 10.1016/S1470-2045(15)70126-9 10.1016/j.oraloncology.2014.11.017 10.3390/cancers13225798 10.1016/j.ijom.2011.06.018 10.1016/j.oraloncology.2016.11.015 10.14639/0392-100X-suppl.1-41-2021-13 10.1111/odi.13485 10.1007/s00520-017-3934-y 10.1016/j.radonc.2023.109847 10.3390/cancers14061411 10.1016/j.jcms.2017.02.014 |
| ContentType | Journal Article |
| Copyright | 2024 Wiley Periodicals LLC. |
| Copyright_xml | – notice: 2024 Wiley Periodicals LLC. |
| DBID | NPM AAYXX CITATION 7X8 |
| DOI | 10.1111/odi.14941 |
| DatabaseName | PubMed CrossRef MEDLINE - Academic |
| DatabaseTitle | PubMed CrossRef MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic PubMed |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Dentistry |
| EISSN | 1601-0825 |
| ExternalDocumentID | 10_1111_odi_14941 38591808 |
| Genre | Journal Article |
| GroupedDBID | --- .3N .GA 05W 0R~ 10A 123 1OC 29N 33P 34H 3SF 4.4 50Y 50Z 51W 51X 52M 52N 52O 52P 52R 52S 52T 52U 52V 52W 52X 53G 5HH 5LA 5RE 5VS 66C 702 7PT 8-0 8-1 8-3 8-4 8-5 8UM 930 A01 A03 AAESR AAEVG AAHHS AANLZ AAONW AAWTL AAXRX AAZKR ABCQN ABCUV ABJNI ABOCM ABPVW ABQWH ABXGK ACAHQ ACCFJ ACCZN ACGFS ACGOF ACMXC ACPOU ACPRK ACXBN ACXQS ADBBV ADBTR ADEOM ADIZJ ADKYN ADMGS ADOZA ADXAS ADZMN AEEZP AEIGN AEIMD AENEX AEQDE AEUQT AEUYR AFBPY AFEBI AFFPM AFGKR AFPWT AFZJQ AHBTC AHMBA AIACR AITYG AIURR AIWBW AJBDE ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN AMBMR AMYDB ATUGU AZBYB AZVAB BAFTC BFHJK BHBCM BMXJE BROTX BRXPI BY8 C45 CS3 CWXXS D-6 D-7 D-E D-F DCZOG DPXWK DR2 DRFUL DRMAN DRSTM EBS F00 F01 F04 F5P FUBAC G-S G.N GODZA H.X HGLYW HZI HZ~ IHE IX1 J0M K48 KBYEO LATKE LC2 LC3 LEEKS LITHE LOXES LP6 LP7 LUTES LYRES MEWTI MK4 MRFUL MRMAN MRSTM MSFUL MSMAN MSSTM MXFUL MXMAN MXSTM N04 N05 N9A NF~ NPM O66 O9- OIG OVD P2P P2W P2X P2Z P4B P4D PQQKQ Q.N Q11 QB0 R.K ROL RX1 SUPJJ TEORI UB1 W8V W99 WBKPD WBNRW WIH WIJ WIK WOHZO WPGGZ WQJ WRC WXI WXSBR XG1 YFH ZZTAW ~IA ~WT AAMNL AAYXX CITATION LH4 7X8 |
| ID | FETCH-LOGICAL-c245t-be03dd7daad0bbcbbbd7f5f6f176ec553bc4e694cffe27558c53f2636f5dba653 |
| ISSN | 1354-523X |
| IngestDate | Sat Aug 17 05:36:33 EDT 2024 Thu Nov 21 21:37:34 EST 2024 Sat Nov 02 12:15:16 EDT 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | radiotherapy tooth extraction osteoradionecrosis |
| Language | English |
| License | 2024 Wiley Periodicals LLC. |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c245t-be03dd7daad0bbcbbbd7f5f6f176ec553bc4e694cffe27558c53f2636f5dba653 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ORCID | 0000-0001-9928-4100 0000-0002-8637-2029 |
| PMID | 38591808 |
| PQID | 3035074639 |
| PQPubID | 23479 |
| ParticipantIDs | proquest_miscellaneous_3035074639 crossref_primary_10_1111_odi_14941 pubmed_primary_38591808 |
| PublicationCentury | 2000 |
| PublicationDate | 2024-04-09 |
| PublicationDateYYYYMMDD | 2024-04-09 |
| PublicationDate_xml | – month: 04 year: 2024 text: 2024-04-09 day: 09 |
| PublicationDecade | 2020 |
| PublicationPlace | Denmark |
| PublicationPlace_xml | – name: Denmark |
| PublicationTitle | Oral diseases |
| PublicationTitleAlternate | Oral Dis |
| PublicationYear | 2024 |
| References | e_1_2_9_30_1 e_1_2_9_31_1 e_1_2_9_11_1 e_1_2_9_34_1 e_1_2_9_10_1 e_1_2_9_32_1 e_1_2_9_12_1 e_1_2_9_33_1 Herrera‐Barraza V. (e_1_2_9_15_1) 2022; 59 Castagnola R. (e_1_2_9_9_1) 2023; 23 Lodi G. (e_1_2_9_23_1) 2021; 2 e_1_2_9_38_1 e_1_2_9_14_1 e_1_2_9_39_1 e_1_2_9_17_1 e_1_2_9_36_1 e_1_2_9_16_1 e_1_2_9_37_1 e_1_2_9_19_1 e_1_2_9_18_1 e_1_2_9_41_1 e_1_2_9_42_1 Gomez‐Millan J. (e_1_2_9_13_1) 2013; 20 e_1_2_9_20_1 e_1_2_9_40_1 e_1_2_9_22_1 e_1_2_9_21_1 Regaud C. (e_1_2_9_35_1) 1922; 87 e_1_2_9_46_1 e_1_2_9_24_1 e_1_2_9_43_1 e_1_2_9_8_1 e_1_2_9_7_1 e_1_2_9_6_1 e_1_2_9_5_1 e_1_2_9_4_1 Thereza‐Bussolaro C. (e_1_2_9_44_1) 2019; 48 e_1_2_9_2_1 Wongmanee S. (e_1_2_9_47_1) 2023; 2023 Wang C. (e_1_2_9_45_1) 2020; 29 e_1_2_9_26_1 Berrone M. (e_1_2_9_3_1) 2021; 14 e_1_2_9_25_1 e_1_2_9_28_1 e_1_2_9_27_1 e_1_2_9_29_1 |
| References_xml | – volume: 48 start-page: 720 issue: 6 year: 2019 ident: e_1_2_9_44_1 article-title: Maxillary osteotomy complications in piezoelectric surgery compared to conventional surgical techniques: A systematic review publication-title: International Journal of Oral and Maxillofacial Surgery doi: 10.1016/j.ijom.2019.01.001 contributor: fullname: Thereza‐Bussolaro C. – ident: e_1_2_9_7_1 doi: 10.1034/j.1600-051X.2003.00366.x – ident: e_1_2_9_22_1 doi: 10.1002/lary.28066 – ident: e_1_2_9_18_1 doi: 10.1902/jop.2007.070210 – volume: 2023 start-page: 1 issue: 15 year: 2023 ident: e_1_2_9_47_1 article-title: Osteoradionecrosis after mandibulotomy and marginal mandibulectomy in patients with oral cancer publication-title: Cureus contributor: fullname: Wongmanee S. – ident: e_1_2_9_28_1 doi: 10.1002/hed.23995 – ident: e_1_2_9_46_1 doi: 10.1016/j.oraloncology.2021.105604 – ident: e_1_2_9_10_1 doi: 10.1002/hed.23949 – volume: 20 start-page: 361 issue: 18 year: 2013 ident: e_1_2_9_13_1 article-title: Current status of IMRT in head and neck cancer publication-title: Reports of Practical Oncology and Radiotherapy contributor: fullname: Gomez‐Millan J. – volume: 29 issue: 1 year: 2020 ident: e_1_2_9_45_1 article-title: Preventing alveolar osteitis after molar extraction using chlorhexidine rinse and gel: A meta‐analysis of randomized controlled trials publication-title: The Journal of Nursing Research doi: 10.1097/jnr.0000000000000401 contributor: fullname: Wang C. – ident: e_1_2_9_17_1 doi: 10.3390/dj10070121 – ident: e_1_2_9_5_1 doi: 10.1016/0196-0709(90)90084-9 – ident: e_1_2_9_14_1 doi: 10.4103/0975-5950.183870 – ident: e_1_2_9_29_1 doi: 10.1007/s10006-019-00783-0 – ident: e_1_2_9_11_1 doi: 10.1016/j.radonc.2004.08.021 – ident: e_1_2_9_27_1 doi: 10.1177/0194599810396290 – ident: e_1_2_9_38_1 doi: 10.3390/cancers14194746 – ident: e_1_2_9_25_1 doi: 10.1016/0278-2391(83)90294-X – ident: e_1_2_9_31_1 doi: 10.1016/j.joms.2003.08.009 – ident: e_1_2_9_36_1 doi: 10.1054/ijom.2002.0332 – ident: e_1_2_9_39_1 doi: 10.1111/jcpe.13286 – ident: e_1_2_9_30_1 doi: 10.1016/j.ijom.2010.10.005 – ident: e_1_2_9_43_1 doi: 10.3322/caac.21660 – volume: 23 start-page: 357 issue: 1 year: 2023 ident: e_1_2_9_9_1 article-title: Clinical outcomes of teeth adjacent to the site of mandibulotomy or mandibulectomy in patients with head and neck cancer: Results from a multidisciplinary mono‐institutional head and neck tumor board publication-title: BMC Oral Health doi: 10.1186/s12903-023-03050-7 contributor: fullname: Castagnola R. – ident: e_1_2_9_33_1 doi: 10.1002/hed.26611 – volume: 87 start-page: 629 year: 1922 ident: e_1_2_9_35_1 article-title: Sur la sensibilite du tissu osseux normal vis‐a‐vis des rayons X et gamma et sur la mecanisme de l'osteoradionecrose publication-title: CR Society of Biology contributor: fullname: Regaud C. – ident: e_1_2_9_21_1 doi: 10.1007/s00405-023-07885-2 – ident: e_1_2_9_24_1 doi: 10.1016/j.mayocp.2015.12.017 – volume: 59 start-page: 593 issue: 4 year: 2022 ident: e_1_2_9_15_1 article-title: Complications post simple exodontia: A systematic review publication-title: Dental and Medical Problems doi: 10.17219/dmp/144596 contributor: fullname: Herrera‐Barraza V. – ident: e_1_2_9_16_1 doi: 10.1111/j.1601-0825.2006.01351.x – ident: e_1_2_9_8_1 doi: 10.1016/j.joen.2019.12.005 – ident: e_1_2_9_12_1 doi: 10.1016/j.joms.2022.04.009 – ident: e_1_2_9_26_1 doi: 10.1016/j.radonc.2022.05.031 – ident: e_1_2_9_42_1 doi: 10.1007/s00066-015-0875-6 – ident: e_1_2_9_4_1 doi: 10.1016/S1470-2045(15)70126-9 – ident: e_1_2_9_40_1 doi: 10.1016/j.oraloncology.2014.11.017 – ident: e_1_2_9_20_1 doi: 10.3390/cancers13225798 – ident: e_1_2_9_2_1 doi: 10.1016/j.ijom.2011.06.018 – ident: e_1_2_9_32_1 doi: 10.1016/j.oraloncology.2016.11.015 – volume: 14 start-page: S124 issue: 1 year: 2021 ident: e_1_2_9_3_1 article-title: Cooperation between ENT surgeon and dentist in head and neck oncology publication-title: Acta Otorhinolaryngologica Italica doi: 10.14639/0392-100X-suppl.1-41-2021-13 contributor: fullname: Berrone M. – volume: 2 start-page: CD003811 issue: 2 year: 2021 ident: e_1_2_9_23_1 article-title: Antibiotics to prevent complications following tooth extractions publication-title: Cochrane Database of Systematic Reviews contributor: fullname: Lodi G. – ident: e_1_2_9_19_1 doi: 10.1111/odi.13485 – ident: e_1_2_9_41_1 doi: 10.1007/s00520-017-3934-y – ident: e_1_2_9_6_1 doi: 10.1016/j.radonc.2023.109847 – ident: e_1_2_9_37_1 doi: 10.3390/cancers14061411 – ident: e_1_2_9_34_1 doi: 10.1016/j.jcms.2017.02.014 |
| SSID | ssj0017932 |
| Score | 2.4530282 |
| Snippet | To evaluate osteoradionecrosis (ORN) incidence in a cohort of patients undergoing tooth extraction (TE) before radiotherapy (RT) for head and neck cancers.
The... AIMSTo evaluate osteoradionecrosis (ORN) incidence in a cohort of patients undergoing tooth extraction (TE) before radiotherapy (RT) for head and neck... |
| SourceID | proquest crossref pubmed |
| SourceType | Aggregation Database Index Database |
| Title | Osteoradionecrosis incidence in pre-radiation teeth extractions: A prospective study |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/38591808 https://search.proquest.com/docview/3035074639 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtZ1La9wwEIBFk0LbS0nT16ZpUUtvxbDR0-4tNJvmkGQLdSA3o2drKLthH_8_M5bXXhMCyaEXI2QszHxmPBrNg5CvvBBHIeiYOS1EJnITMluMZWZUHpnJrSgcJief_daX1_nJREz6Jnj93H8lDXPAGjNnH0G7WxQmYAzM4QrU4fog7lPABlg9ViDCX2CNAVcutQ5tQsYXIcPbCfwqhNXfb6CgFynBYZky1UGtblIwtwrQtjbsdNEf7GxFyt-EgdP1Zz13jRu2a951AXa6wf6M9cALW5o__2oTsUJknwXR-iFYCl9J2i4k3anQM5GnPOZ7NPPc16Cbi1Tralj9-nJanV6dn1fl5LrcIU8ZKA7shcD5r-5UCKZYWx0Ko7G6xYY2xT0bhcZgKPfIy9bSp8cJ0SvyJMz2yfMTjM7CBnv75NlFG9fwmpR3qdGOGozogBptqNEtat_pMd1iRhtmb8jV6aT8cZa1_S4yx4RcZTaMuffaG-PH1jprrddRRhWPtApOSm6dCKoQLsbAtJS5kzwyxVWU3hol-VuyO4PXfE-oZ1ExE7ny0gmjnNXSceOC0g439GpEvmwkVt2ksibVZjsIYq0asY7I540sK1A6eJJkZmG-XlYcz6O1AOt2RN4lIXfLcKyImI_zgwc8_YG86D-lQ7K7WqzDR7Kz9OtPDflbxExZ3w |
| link.rule.ids | 315,782,786,27934,27935 |
| linkProvider | Wiley-Blackwell |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Osteoradionecrosis+incidence+in+pre-radiation+teeth+extractions%3A+A+prospective+study&rft.jtitle=Oral+diseases&rft.au=Rupe%2C+C&rft.au=Gioco%2C+G&rft.au=Massaccesi%2C+M&rft.au=Tagliaferri%2C+L&rft.date=2024-04-09&rft.eissn=1601-0825&rft_id=info:doi/10.1111%2Fodi.14941&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1354-523X&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1354-523X&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1354-523X&client=summon |