Response to Roldan et al

• Published in: The American journal of gastroenterology Vol. 116; no. 7; p. 1552
• Main Authors: Kårhus, Line Lund, Linneberg, Allan
• Format: Journal Article
• Language: English
• Published: United States Wolters Kluwer 01-07-2021; Wolters Kluwer Health Medical Research, Lippincott Williams & Wilkins
• Subjects: Celiac disease; Disease; Gastroenterology; Mortality; Serology
• ISSN: 0002-9270; 1572-0241
• DOI: 10.14309/ajg.0000000000001231

[...]it is almost per definition not possible to investigate long-term effects of undiagnosed celiac disease confirmed by intestinal biopsies; consequently, we must rely on serological testing. [...]some of the individuals in the seropositive group may not have clinical relevance, and the increased serology might, in some cases, be caused by other conditions or diseases. [...]the difference in mortality could reflect the shorter follow-up time. [...]although our study has weaknesses, e.g., not having performed EMA tests, it adds evidence to the best of our knowledge of the risk of comorbidities in individuals with likely undiagnosed celiac disease and support the need for increased awareness of undetected celiac disease among patients and even in the general population.