Anticancer Potential of the Principal Constituent of Piper nigrum, Piperine: A Comprehensive Review
Black pepper's main component, piperine, is a phytochemical that gives the spice its distinctively pungent flavor, which has made it a staple in human diets for decades and a widely used food item. In addition to its use as a culinary component and preservation agent, it is also employed in tra...
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| Published in: | Curēus (Palo Alto, CA) Vol. 16; no. 2; p. e54425 |
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| Main Authors: | , , , , , |
| Format: | Journal Article |
| Language: | English |
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Cureus Inc
18-02-2024
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| Abstract | Black pepper's main component, piperine, is a phytochemical that gives the spice its distinctively pungent flavor, which has made it a staple in human diets for decades and a widely used food item. In addition to its use as a culinary component and preservation agent, it is also employed in traditional medicine for a diverse range of objectives, a practice that has been substantiated by existing scientific investigations on its physiological impacts in the majority of instances. Piperine contains various bioactive effects, such as antibacterial activity, in addition to several physiological benefits that could help overall human health, such as immunomodulatory, hepatoprotective, antioxidant, antimetastatic, anticancer, and many more properties that have been established. Clinical trials revealed that this phytochemical has exceptional antioxidant, anticancer, and drug availability-enhancing properties, as well as immunomodulatory potential. The different components of evidence indicate the therapeutic potential of piperine and underscore the importance of incorporating it into both broad health-promoting interventions and supplementary treatment pharmaceutical formulations. This inclusion can enhance the bioavailability of other therapeutic medications, including those used in chemotherapy. |
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| AbstractList | Black pepper's main component, piperine, is a phytochemical that gives the spice its distinctively pungent flavor, which has made it a staple in human diets for decades and a widely used food item. In addition to its use as a culinary component and preservation agent, it is also employed in traditional medicine for a diverse range of objectives, a practice that has been substantiated by existing scientific investigations on its physiological impacts in the majority of instances. Piperine contains various bioactive effects, such as antibacterial activity, in addition to several physiological benefits that could help overall human health, such as immunomodulatory, hepatoprotective, antioxidant, antimetastatic, anticancer, and many more properties that have been established. Clinical trials revealed that this phytochemical has exceptional antioxidant, anticancer, and drug availability-enhancing properties, as well as immunomodulatory potential. The different components of evidence indicate the therapeutic potential of piperine and underscore the importance of incorporating it into both broad health-promoting interventions and supplementary treatment pharmaceutical formulations. This inclusion can enhance the bioavailability of other therapeutic medications, including those used in chemotherapy. |
| Author | Umapathy, Vidhya Rekha Natarajan, Prabhu Manickam S, Bhuminathan Dhanavel, Anandhi P, Vijayalakshmi Kesavan, R |
| Author_xml | – sequence: 1 givenname: Vidhya Rekha surname: Umapathy fullname: Umapathy, Vidhya Rekha organization: Public Health Dentistry, Meenakshi Ammal Dental College and Hospital, Meenakshi Academy of Higher Education and Research (MAHER), Chennai, IND – sequence: 2 givenname: Anandhi surname: Dhanavel fullname: Dhanavel, Anandhi organization: Biochemistry, Meenakshi Academy of Higher Education and Research (MAHER), Chennai, IND – sequence: 3 givenname: R surname: Kesavan fullname: Kesavan, R organization: Public Health Dentistry, Thai Moogambigai Dental College and Hospital, Chennai, IND – sequence: 4 givenname: Prabhu Manickam surname: Natarajan fullname: Natarajan, Prabhu Manickam organization: Clinical Sciences/Periodontics, College of Dentistry, Ajman University, Ajman, ARE – sequence: 5 givenname: Bhuminathan surname: S fullname: S, Bhuminathan organization: Public Health Dentistry, Sree Balaji Dental College & Hospital, Chennai, IND – sequence: 6 givenname: Vijayalakshmi surname: P fullname: P, Vijayalakshmi organization: Biotechnology, Holy Cross College (Autonomous) Tiruchirappalli, Tiruchirappalli, IND |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/38405638$$D View this record in MEDLINE/PubMed |
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| Snippet | Black pepper's main component, piperine, is a phytochemical that gives the spice its distinctively pungent flavor, which has made it a staple in human diets... Black pepper’s main component, piperine, is a phytochemical that gives the spice its distinctively pungent flavor, which has made it a staple in human diets... |
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| SubjectTerms | Apoptosis Breast cancer Cell cycle Cell growth Colorectal cancer Cytochrome FDA approval Immunotherapy Investigations Medicine Melanoma Oils & fats Ovarian cancer |
| Title | Anticancer Potential of the Principal Constituent of Piper nigrum, Piperine: A Comprehensive Review |
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