Pericardial, But Not Hepatic, Fat by CT Is Associated With CV Outcomes and Structure

• Published in: JACC. Cardiovascular imaging Vol. 10; no. 9; pp. 1016 - 1027
• Main Authors: Shah, Ravi V., MD, Anderson, Amanda, RN BSN, Ding, Jingzhong, PhD, Budoff, Matthew, MD, Rider, Oliver, MD, Petersen, Steffen E., MD, MPH, Jensen, Majken Karoline, PhD, Koch, Manja, PhD, Allison, Matthew, MD, Kawel-Boehm, Nadine, MD, Wisocky, Jessica, NP, Jerosch-Herold, Michael, PhD, Mukamal, Kenneth, MD, Lima, Joao A.C., MD, Murthy, Venkatesh L., MD, PhD
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01-09-2017
• Subjects: cardiac magnetic resonance imaging; Cardiovascular; hepatic fat; obesity; pericardial fat; remodeling; remodeling; cardiac magnetic resonance imaging; ASCVD; LVEF; LV; atherosclerotic cardiovascular disease; pericardial fat; left ventricular ejection fraction; IDI; integrated discrimination index; left ventricular; obesity; BMI; computed tomography; homeostatic model assessment for insulin resistance; cardiovascular disease; body mass index; CI; CMR; CVD; CT; HOMA-IR; GAM; generalized additive model; coronary heart disease; confidence interval; cardiac magnetic resonance; hepatic fat; CHD
• DOI: 10.1016/j.jcmg.2016.10.024
• EISSN: 1876-7591
• ISSN: 1936-878X

Abstract Objectives The study sought to determine the associations between local (pericardial) fat and incident cardiovascular disease (CVD) events and cardiac remodeling independent of markers of overall adiposity. Background The impact of pericardial fat—a local fat depot encasing the heart—on myocardial function and long-term CV prognosis independent of systemic consequences of adiposity or hepatic fat is an area of active debate. Methods We studied 4,234 participants enrolled in the MESA (Multi-Ethnic Study of Atherosclerosis) study with concomitant cardiac magnetic resonance imaging and computed tomography (CT) measurements for pericardial fat volume and hepatic attenuation (a measure of liver fat). Poisson and Cox regression were used to estimate the annualized risk of incident hard atherosclerotic CVD (ASCVD), all-cause death, heart failure, all-cause CVD, hard coronary heart disease, and stroke as a function of pericardial and hepatic fat. Generalized additive models were used to assess the association between cardiac magnetic resonance indices of left ventricular (LV) structure and function and pericardial fat. Models were adjusted for relevant clinical, demographic, and cardiometabolic covariates. Results MESA study participants with higher pericardial and hepatic fat were more likely to be older, were more frequently men, and had a higher prevalence of cardiometabolic risk factors (including dysglycemia, dyslipdemia, hypertension), as well as adiposity-associated inflammation. Over a median 12.2-year follow-up (interquartile range: 11.6 to 12.8 years), pericardial fat was associated with a higher rate of incident hard ASCVD (standardized hazard ratio: 1.22; 95% confidence interval: 1.10 to 1.35; p = 0.0001). Hepatic fat by CT was not significantly associated with hard ASCVD (standardized hazard ratio: 0.96; 95% confidence interval: 0.86 to 1.08; p = 0.52). Higher pericardial fat was associated with greater indexed LV mass (37.8 g/m2.7 vs. 33.9 g/m2.7 , highest quartile vs. lowest quartile; p < 0.01), LV mass-to-volume ratio (1.2 vs. 1.1, highest quartile vs. lowest quartile; p < 0.01). In adjusted models, a higher pericardial fat volume was associated with greater LV mass (p < 0.0001) and concentricity (p < 0.0001). Conclusions Pericardial fat is associated with poorer CVD prognosis and LV remodeling, independent of insulin resistance, inflammation, and CT measures of hepatic fat.