Exploring the structure-activity relationship (SAR) of Schiff bases as effective compounds in scavenging free radicals

•Two Schiff base derivatives synthesized from 2‑hydroxy-1-naphthaldehyde were synthesized.•DFT calculations show that 1 is more stable as an enol tautomer, while 2 is a keto.•The free radical scavenging potential of 1 and 2 was studied by DPPH and ABTS assay.•The SAR evaluation also included Schiff...

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Bibliographic Details

Published in:	Journal of molecular structure Vol. 1315; p. 138729
Main Authors:	Nunes, Ianka J., Dias, Renieidy F.C., da Silva, Alecia F., Ferreira, Wesley V., Cunico, Wilson, Couto, Gabriel T., Bianchini, Daniela, Casagrande, Osvaldo de L., Saffi, Jenifer, Pinheiro, Adriana C.
Format:	Journal Article
Language:	English
Published:	Elsevier B.V 05-11-2024
Subjects:	ADMETox studies Cytotoxicity DFT calculations Scavenging activity Schiff-base compounds Structure-activity relationship (SAR) Scavenging activity Cytotoxicity Structure-activity relationship (SAR) Schiff-base compounds ADMETox studies DFT calculations
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