Quinazoline: An update on current status against convulsions

•Nitrogen rich species quinazolines are charming target against convulsions.•This review collates the current research finished on quinazoline scaffold as anticonvulsants reported in literature by researchers in the years (2015–2020).•This work is helpful for researchers who planning to design and d...

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Bibliographic Details
Published in:	Journal of molecular structure Vol. 1248; p. 131384
Main Authors:	Cheke, Rameshwar S., Shinde, Sachin D., Ambhore, Jaya P., Chaudhari, Suraj R., Bari, Sanjay B.
Format:	Journal Article
Language:	English
Published:	Elsevier B.V 15-01-2022
Subjects:	Anticonvulsant activity MES and scPTZ screening Quinazoline synthesis Structural activity relationship Structural activity relationship AMPA BBB scPTZ SAR Quinazoline synthesis GAA Anticonvulsant activity CNS EDG RMSD Et3N TD50 AEDs GABAA EWG p-TsOH MES and scPTZ screening NMDA MES ED50 SOCl2 DMF
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Summary:	•Nitrogen rich species quinazolines are charming target against convulsions.•This review collates the current research finished on quinazoline scaffold as anticonvulsants reported in literature by researchers in the years (2015–2020).•This work is helpful for researchers who planning to design and development of quinazoline as anticonvulsant. Epilepsy is one of the most frequent chronic neurological disorder extremely threatening the life and good health. More than 70 million individuals suffering from epilepsy worldwide and it required long-term therapy. Many epileptic patients not fully satisfied with currently available treatment likewise, frequent drugs have shown a lack of efficacy, side effects, and drug interaction. Therefore, the search for antiepileptics with greater selectivity and lesser toxicity continues to be the focus and task in medicinal chemistry. Quinazoline represents a distinct class of biologically active nitrogen heterocyclic nucleus with great anticonvulsants potential. In the past few years, persistent medicinal chemistry efforts have developed diverse structurally functionalized potential quinazoline derivatives for anticonvulsant potential. This work report covers most current efforts taken in the design, development, and anticonvulsant efficacy of quinazoline analogs from 2015 to 2020. [Display omitted]
ISSN:	0022-2860 1872-8014
DOI:	10.1016/j.molstruc.2021.131384