Negative association between lipoprotein associated phospholipase A2 activity and baroreflex sensitivity in subjects with high normal blood pressure and a positive family history of hypertension

• Published in: Physiological research Vol. 70; no. 2; pp. 183 - 191
• Main Authors: Čelovská, D, Vlčková, K, Gonsorčík, J
• Format: Journal Article
• Language: English
• Published: Czech Republic Institute of Physiology 30-04-2021; Institute of Physiology of the Czech Academy of Sciences
• Subjects: 1-Alkyl-2-acetylglycerophosphocholine Esterase - blood; Adult; Age; Antihypertensives; Automation; Autonomic Nervous System - physiopathology; Baroreceptors; Baroreflex; Biomarkers; Biomarkers - blood; Blood Pressure; Body mass index; Cardiology; Case-Control Studies; Diabetes; Disease; Family medical history; Female; Females; Humans; Hypertension; Hypertension - blood; Hypertension - diagnosis; Hypertension - enzymology; Hypertension - physiopathology; Inflammation; Lipoproteins; Male; Medical History Taking; Metabolism; Middle Aged; Nervous system; Phospholipase A2; Predictive Value of Tests; Reflexes; Risk Factors; Single photon emission computed tomography; Japan
• ISSN: 0862-8408; 1802-9973
• DOI: 10.33549/physiolres.934467

The relationship between baroreflex sensitivity (BRS) and inflammatory vascular biomarker Lipoprotein associated phospholipase A2 (Lp-PLA2) in subjects with high normal blood pressure (HNBP, prehypertensives) with a positive family history of hypertension (FHH+) and hypertension history free control subjects (FHH-) was evaluated. A total of 24 HNBP participants (age 39.5 ± 2.5 years, 18 male/ 6 female) were studied. 14 HNBP subjects FHH+ were compared to 10 HNBP participants FHH-, being of similar age and body mass index. BRS (ms/mmHg) was determined by the sequence and spectral methods (five-minute non-invasive beat-to-beat recording of blood pressure and RR interval, controlled breathing at a frequency of 0.33 Hz). Venous blood was analyzed for Lp-PLA2 biomarker of vascular inflammation and atherothrombotic activity. A significant negative correlation between spontaneous BRS obtained by both methods and systolic blood pressure (BP) was present (BRS spect r = -0.54, P<0.001, BRS seq r = -0.59, P<0.001). BRS obtained by sequence and spectral methods were reduced in HNBP FHH+ compared to the group of HNBP FHH- (P = 0.0317 BRS seq, P = 0.0395 BRS spect). Lp-PLA2 was significantly higher in HNBP FHH+ compared to FHH- controls (P<0.05). Lp-PLA2 was negatively correlated with BRS obtained by sequence method (r = -0.798, R2 = 0.636, P<0.001) in the HNBP FHH+ subjects. These findings demonstrate that reduced baroreflex sensitivity, as a marker of autonomic dysfunction, is associated with vascular inflammation, predominantly in otherwise healthy participants with a positive family history of hypertension who could predispose to increased risk of hypertension. We conclude that our transversal study suggests that a lowbaroreflex sensitivity could be an early sign of autonomic dysfunction even in the prehypertensive period, and to corroborate these findings, a longitudinal study is needed.