Cumulative Health Risk from Exposure Load (CHREL): Looking at multi-chemical exposures through the lens of biomonitoring guidance values

• Published in: Toxicology letters Vol. 401; pp. 139 - 149
• Main Authors: Willey, Jeff B., Liang, Chun Lei, Pollock, Tyler, Khoury, Cheryl, Thomson, Errol M., Walker, Mike, St-Amand, Annie
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01-11-2024
• Subjects: Biomonitoring; Canadian Health Measures Survey; Chemical mixture; CHMS; Exposure; Guidance value; HB2GV; Health risk; Multi-chemical; Canadian Health Measures Survey; Biomonitoring; HB2GV; Chemical mixture; CHMS; Exposure; Guidance value; Multi-chemical; Health risk; chemical mixture; health risk; biomonitoring; exposure; guidance value; multi-chemical
• DOI: 10.1016/j.toxlet.2024.09.006
• EISSN: 1879-3169
• ISSN: 0378-4274; 1879-3169

Exposure load (EL) is an indicator of multiple chemical exposures based on human biomonitoring data. We used EL methodology and human biomonitoring health-based guidance values (HB2GVs) as exposure thresholds to create a new metric called Cumulative Health Risk from Exposure Load (CHREL). HB2GVs are derived by calculating the concentration of a biomarker consistent with a health protective exposure guidance value. CHREL analysis was conducted using Canadian Health Measures Survey (CHMS) cycle 3 and 4 biomonitoring data. Based on 18 chemicals, more than half of the Canadian population had an estimated CHRELTOTAL of 1 or more, indicative of chemical exposures potentially above selected exposure guidance values. Females had a significantly lower CHRELTOTAL compared to males, 12–19 year olds had a lower CHRELTOTAL compared to older age groups (significant compared to 40–59 year olds), and nonsmokers had a significantly lower CHRELTOTAL than smokers. Small segments of the population had a CHRELLIVER or a CHRELNERV of 1 or more, indicating exposures potentially above guideline levels for chemicals affecting the liver or nervous system. CHRELCANC was calculated based on 6 chemicals with HB2GVs derived for cancer endpoints. At the 10−5 risk level, most people had an estimated CHRELCANC of 3, indicative of multiple chemicals that may exceed negligible cancer risk. The most important contributors to exposures above HB2GVs were inorganic arsenic, mercury, acrylamide, xylenes, benzene and triclosan. Keeping certain assumptions, uncertainties and limitations in mind, the CHREL indicator can be used to obtain a picture of potential cumulative health risks from combined chemical exposures in a population, and as a comparative measure between subpopulations, including vulnerable subgroups.
•We created a metric called Cumulative Health Risk from Exposure Load (CHREL).•CHREL is an indicator of potential health risks from multiple chemical exposures.•CHREL uses human biomonitoring guidance values as exposure thresholds.•Females had lower CHREL than males; adolescents had lower CHREL than older adults.•Nonsmokers had lower CHREL than people who smoke.