A calcium hypothesis of antidepressant action
The biogenic amine hypothesis of affective disorders has served as a valuable model for investigations concerning the mechanism of action of antidepressant drugs. Despite numerous publications on the subject, the manner in which tricyclic antidepressants elicit their therapeutic effect remains unkno...
Saved in:
| Published in: | Medical hypotheses Vol. 10; no. 2; p. 207 |
|---|---|
| Main Authors: | , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
United States
01-02-1983
|
| Subjects: | |
| Online Access: | Get more information |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | The biogenic amine hypothesis of affective disorders has served as a valuable model for investigations concerning the mechanism of action of antidepressant drugs. Despite numerous publications on the subject, the manner in which tricyclic antidepressants elicit their therapeutic effect remains unknown. Recent findings which involve tricyclic antidepressant interactions with thyroid hormone, along with an appraisal of the older literature concerned with dyscalcemias and affective disorders, provides the basis for an hypothesis featuring a role for calcium in mediating antidepressant responses. |
|---|---|
| AbstractList | The biogenic amine hypothesis of affective disorders has served as a valuable model for investigations concerning the mechanism of action of antidepressant drugs. Despite numerous publications on the subject, the manner in which tricyclic antidepressants elicit their therapeutic effect remains unknown. Recent findings which involve tricyclic antidepressant interactions with thyroid hormone, along with an appraisal of the older literature concerned with dyscalcemias and affective disorders, provides the basis for an hypothesis featuring a role for calcium in mediating antidepressant responses. |
| Author | Kaiser, E A Hammond, R P Swonger, A K Ortolano, G A |
| Author_xml | – sequence: 1 givenname: G A surname: Ortolano fullname: Ortolano, G A – sequence: 2 givenname: A K surname: Swonger fullname: Swonger, A K – sequence: 3 givenname: E A surname: Kaiser fullname: Kaiser, E A – sequence: 4 givenname: R P surname: Hammond fullname: Hammond, R P |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/6133209$$D View this record in MEDLINE/PubMed |
| BookMark | eNo9jktLAzEURrOo1Lb6DxSy1EX0JjeTx7IUq0LBja7LnUxCI50Hk-mi_17B4uo7nMXhW7JZ13eRsTsJTxKkeQYEI7yz9sHhowdQWlQztvjX12xZyjcAeI1uzuZGIirwCybWPNAx5FPLD-ehnw6x5ML7xKmbchOHMZbyi5zClPvuhl0lOpZ4e9kV-9q-fG7exO7j9X2z3omgtJxEjYQA2pAKJiUdDKYavdVBRQ1exqBAVpVtjIWEWukmOHKJggXjai9Jrdj9X3c41W1s9sOYWxrP-8tt9QMLVkP1 |
| CitedBy_id | crossref_primary_10_1002_hup_186 crossref_primary_10_1111_j_1600_0447_1989_tb01296_x crossref_primary_10_1196_annals_1300_016 crossref_primary_10_1016_0014_2999_88_90813_8 crossref_primary_10_1016_0306_3623_85_90141_7 |
| ContentType | Journal Article |
| DBID | CGR CUY CVF ECM EIF NPM |
| DOI | 10.1016/0306-9877(83)90024-5 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) |
| DatabaseTitleList | MEDLINE |
| Database_xml | – sequence: 1 dbid: ECM name: MEDLINE url: https://search.ebscohost.com/login.aspx?direct=true&db=cmedm&site=ehost-live sourceTypes: Index Database |
| DeliveryMethod | no_fulltext_linktorsrc |
| Discipline | Medicine |
| ExternalDocumentID | 6133209 |
| Genre | Journal Article |
| GroupedDBID | --- --K --M .1- .FO .GJ .~1 0R~ 1B1 1P~ 1RT 1~. 1~5 29M 4.4 457 4G. 53G 5GY 5RE 5VS 7-5 71M 8P~ 9JM AABNK AACTN AAEDT AAEDW AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AAWTL AAXKI AAXUO ABBQC ABFNM ABGSF ABJNI ABLJU ABMAC ABMZM ABUDA ABXDB ABZDS ACDAQ ACGFS ACRLP ADBBV ADEZE ADMUD ADUVX AEBSH AEHWI AEKER AENEX AEVXI AFCTW AFFNX AFJKZ AFKWA AFRHN AFTJW AFXIZ AGHFR AGRDE AGUBO AGYEJ AHHHB AIEXJ AIKHN AITUG AJOXV AJRQY AJUYK AKRWK ALCLG ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ANZVX ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC BNPGV CAG CGR COF CS3 CUY CVF DU5 EBS ECM EFJIC EIF EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HEA HMK HMO HVGLF HZ~ IHE J1W KOM LZ2 M29 M41 MO0 N9A NPM O-L O9- OAUVE OGGZJ OZT P-8 P-9 P2P PC. Q38 R2- RIG ROL RPZ SAE SCC SDF SDG SDP SEL SES SEW SPCBC SSH SSP SSU SSZ T5K UHS WUQ Z5R ZGI ~G- |
| ID | FETCH-LOGICAL-c241t-b3a30046a2c6ff4c63fb3974c2e4091ec201557d670f3424dc8a8fac7068b91a2 |
| ISSN | 0306-9877 |
| IngestDate | Sat Sep 28 08:34:26 EDT 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 2 |
| Language | English |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c241t-b3a30046a2c6ff4c63fb3974c2e4091ec201557d670f3424dc8a8fac7068b91a2 |
| PMID | 6133209 |
| ParticipantIDs | pubmed_primary_6133209 |
| PublicationCentury | 1900 |
| PublicationDate | 1983-Feb |
| PublicationDateYYYYMMDD | 1983-02-01 |
| PublicationDate_xml | – month: 02 year: 1983 text: 1983-Feb |
| PublicationDecade | 1980 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Medical hypotheses |
| PublicationTitleAlternate | Med Hypotheses |
| PublicationYear | 1983 |
| SSID | ssj0009438 |
| Score | 1.3026263 |
| Snippet | The biogenic amine hypothesis of affective disorders has served as a valuable model for investigations concerning the mechanism of action of antidepressant... |
| SourceID | pubmed |
| SourceType | Index Database |
| StartPage | 207 |
| SubjectTerms | Animals Antidepressive Agents, Tricyclic - therapeutic use Biogenic Amines - biosynthesis Calcium - blood Calcium - cerebrospinal fluid Calcium - metabolism Chickens Depression - drug therapy Depression - metabolism Dogs Drug Interactions Humans Neurotransmitter Agents - metabolism Parathyroid Glands - physiopathology Rats Thyroid Hormones - metabolism Thyroid Hormones - therapeutic use |
| Title | A calcium hypothesis of antidepressant action |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/6133209 |
| Volume | 10 |
| hasFullText | |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3dS8MwEA9OUfYifuI3fXCgjGCXZG32OOZUkCm4Cb6NNh-4h32gG-J_76VJmzlR9MGXUpI2tPe7XO-u94HQqSAspSwWOFQMDBTNKeZKcNh4XMiUxKm0rotufPfEL9us7eN0_di_Ig1jgLXJnP0D2sWiMADngDkcAXU4_gr3ZhWoLgazYfX5fWLSq1zFEaDgwIW9JiasXBSI5P2c3C-b_DYfXHj_MgUDOOvRXb32zs_u29i4BK10Kbylt-ZflM2h8Zca_7jrX_zgMsqkTb3jNA9OLgQSmBe4wV3blVx6hnNcQuZFoe1m-0VEW29BsVbFtDuumI8iaAu4Pn8LEHYyzGACnYOSrIzCz5MLpbPdTAmVQA8yqnKr4wsys6zLefEceVplLbooxs44PXfPVUarbrUF-yPTQ3obaN0ZEEHTIr-JltRoC611XIjENsLNwDFA4BkgGOvgMwMElgF20ONVu9e6wa4nBoZdVZvilCamRlqUEBFpzUREdQoqJRNEgaVeU4IYJTiWURxqygiTgidcJyIOI542agnZRcuj8UjtoaBOuCCS6CRVDcYE5YlMQyHDSIJNHqp4H-3aF-1PbOGTvqPAwXcTh6js-eYIrWjYU-oYlV7l7CSj_gci_zmu |
| link.rule.ids | 782 |
| linkProvider | EBSCOhost |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=A+calcium+hypothesis+of+antidepressant+action&rft.jtitle=Medical+hypotheses&rft.au=Ortolano%2C+G+A&rft.au=Swonger%2C+A+K&rft.au=Kaiser%2C+E+A&rft.au=Hammond%2C+R+P&rft.date=1983-02-01&rft.issn=0306-9877&rft.volume=10&rft.issue=2&rft.spage=207&rft_id=info:doi/10.1016%2F0306-9877%2883%2990024-5&rft_id=info%3Apmid%2F6133209&rft_id=info%3Apmid%2F6133209&rft.externalDocID=6133209 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0306-9877&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0306-9877&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0306-9877&client=summon |