A calcium hypothesis of antidepressant action

The biogenic amine hypothesis of affective disorders has served as a valuable model for investigations concerning the mechanism of action of antidepressant drugs. Despite numerous publications on the subject, the manner in which tricyclic antidepressants elicit their therapeutic effect remains unkno...

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Bibliographic Details
Published in:	Medical hypotheses Vol. 10; no. 2; p. 207
Main Authors:	Ortolano, G A, Swonger, A K, Kaiser, E A, Hammond, R P
Format:	Journal Article
Language:	English
Published:	United States 01-02-1983
Subjects:	Animals Antidepressive Agents, Tricyclic - therapeutic use Biogenic Amines - biosynthesis Calcium - blood Calcium - cerebrospinal fluid Calcium - metabolism Chickens Depression - drug therapy Depression - metabolism Dogs Drug Interactions Humans Neurotransmitter Agents - metabolism Parathyroid Glands - physiopathology Rats Thyroid Hormones - metabolism Thyroid Hormones - therapeutic use
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Summary:	The biogenic amine hypothesis of affective disorders has served as a valuable model for investigations concerning the mechanism of action of antidepressant drugs. Despite numerous publications on the subject, the manner in which tricyclic antidepressants elicit their therapeutic effect remains unknown. Recent findings which involve tricyclic antidepressant interactions with thyroid hormone, along with an appraisal of the older literature concerned with dyscalcemias and affective disorders, provides the basis for an hypothesis featuring a role for calcium in mediating antidepressant responses.
ISSN:	0306-9877
DOI:	10.1016/0306-9877(83)90024-5