Evaluation of nociception and edema in experimental sciatic nerve compression model in Wistar rats treated with cryotherapy

• Published in: Revista dor Vol. 17; no. 3; pp. 210 - 214
• Main Authors: Karvat, Jhenifer, Kakihata, Camila Mayumi Martin, Vieira, Lizyana, Antunes, Juliana Sobral, Ribeiro, Lucinéia de Fátima Chasko, Bertolini, Gladson Ricardo Flor
• Format: Journal Article
• Language: English
• Published: Sociedade Brasileira para o Estudo da Dor 01-09-2016
• Subjects: CLINICAL NEUROLOGY; CRITICAL CARE MEDICINE; edema; imersão; NEUROSCIENCES; nociceptividade; terapia por frio; traumatismo do nervo periférico; Nociception; Edema; Peripheral nerve trauma; Imersão; Traumatismo do nervo periférico; Terapia por frio; Immersion; Nociceptividade; Cold therapy
• ISSN: 2317-6393; 1806-0013; 2317-6393
• DOI: 10.5935/1806-0013.20160073

ABSTRACT BACKGROUND AND OBJECTIVES: Considering the scarcity of studies addressing cryotherapy to treat peripheral nervous injuries, this study aimed at evaluating nociception and edema in an experimental sciatic nerve compression model with Wistar rats treated with cryotherapy. METHODS: Forty-two rats were randomly distributed in groups: G1 - control, euthanized in the 15th postoperative day; G2, G3 and G4 - submitted to sciatic nerve compression and euthanized in the 3rd, 8th and 15th postoperative day, respectively; G5, G6 and G7 - submitted to sciatic nerve compression and treated with cryotherapy, euthanized in the 3rd, 8th and 15th postoperative day, respectively. Nociception evaluation at injury site and plantar region, and observation of edema were performed before injury, in the 2nd postoperative day and in the day corresponding to euthanasia of each injured group. Mixed ANOVA was used for statistical analysis, considering significant 5%. RESULTS: There has been decreased pain threshold at injury site in injured groups, however there has been increase in the same groups with regard to evaluations in the 8th and 15th postoperative days. Nociception in the plantar region was similar to previous one, however threshold has not increased. With regard to edema, there has been significant difference in evaluations in the 3rd and 2nd postoperative days corresponding to G1, G4 and G7, which had higher values as compared to pre-injury. CONCLUSION: Cryotherapy has not increased nociceptive threshold or decreased the edema.