Atopic Dermatitis in Children

Atopic Dermatitis in Children

Atopic dermatitis (AD) is a chronic, relapsing, highly pruritic skin condition resulting from disruption of the epithelial barrier and associated immune dysregulation in the skin of genetically predisposed hosts. AD generally develops in early childhood, has a characteristic age-dependent distributi...

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Bibliographic Details
Published in:Immunology and allergy clinics of North America Vol. 35; no. 1; pp. 161 - 183
Main Authors: Lyons, Jonathan J., MD, Milner, Joshua D., MD, Stone, Kelly D., MD, PhD
Format: Journal Article
Language:English
Published: Elsevier Inc 01-02-2015
Subjects:
Allergy
Allergy and Immunology
Atopic dermatitis
Eczema
Hyper-IgE syndrome
Netherton syndrome
Netherton syndrome
Allergy
Hyper-IgE syndrome
Atopic dermatitis
Eczema
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Description
Summary:Atopic dermatitis (AD) is a chronic, relapsing, highly pruritic skin condition resulting from disruption of the epithelial barrier and associated immune dysregulation in the skin of genetically predisposed hosts. AD generally develops in early childhood, has a characteristic age-dependent distribution and is commonly associated with elevated IgE, peripheral eosinophilia, and other allergic diseases. Medications such as antihistamines have demonstrated poor efficacy in controlling AD-associated itch. Education of patients regarding the primary underlying defects and provision of a comprehensive skin care plan is essential for disease maintenance and management of flares.
ISSN:0889-8561
1557-8607
DOI:10.1016/j.iac.2014.09.008