The fluoromethyl ether sevoflurane as a fluoride source in halogen-exchange reactions

• Published in: Journal of fluorine chemistry Vol. 88; no. 1; pp. 51 - 54
• Main Authors: Rozov, Leonid A., Lessor, Ralph A., Kudzma, Linas V., Ramig, Keith
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 27-02-1998
• Subjects: Halogen-exchange reaction; Selective fluoride donor; Sevoflurane; Sevoflurane; Halogen-exchange reaction; Selective fluoride donor
• ISSN: 0022-1139; 1873-3328
• DOI: 10.1016/S0022-1139(97)00135-8

Fluoromethyl 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ether (sevoflurane), fluoromethyl 1,1,2,3,3,3-hexafluoropropyl ether, and fluoromethyl 1,2,2,2-tetrafluoroethyl ether are found to be selective fluoride donors in some halogen-exchange reactions. For example, treatment of a mixture of a polychlorinated substrate and one equivalent of sevoflurane with a catalytic amount of antimony pentachloride gives a monofluorinated product and one equivalent of chloromethyl 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ether as by-product.