Metabolic profiling of tryptophan pathways: Implications for obesity and metabolic dysfunction-associated steatotic liver disease

The rise in obesity highlights the need for improved therapeutic strategies, particularly in addressing metabolic dysfunction-associated steatotic liver disease (MASLD). We aim to assess the role of tryptophan metabolic pathways in the pathogenesis of obesity and in the different histological stages...

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Bibliographic Details
Published in:	European journal of clinical investigation Vol. 54; no. 11; p. e14279
Main Authors:	Arto, Carmen, Rusu, Elena Cristina, Clavero-Mestres, Helena, Barrientos-Riosalido, Andrea, Bertran, Laia, Mahmoudian, Razieh, Aguilar, Carmen, Riesco, David, Chicote, Javier Ugarte, Parada, David, Martínez, Salomé, Sabench, Fàtima, Richart, Cristóbal, Auguet, Teresa
Format:	Journal Article
Language:	English
Published:	England Blackwell Publishing Ltd 01-11-2024
Subjects:	Acetic acid Adult Case-Control Studies Catabolism Fatty liver Fatty Liver - metabolism Female Fluxes Gene expression High performance liquid chromatography Humans Indoleacetic acid Indoleacetic Acids Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism Indoles - metabolism Kynurenine - metabolism Kynurenine 3-Monooxygenase - metabolism Liquid chromatography Liver Liver - metabolism Liver diseases Male Metabolic pathways Metabolism Metabolites Middle Aged Obesity Obesity - metabolism Obesity, Morbid - metabolism Pathogenesis Propionic acid Serotonin Serotonin - metabolism Steatosis Therapeutic applications Tryptophan Tryptophan - metabolism serotonin kynurenine metabolic dysfunction‐associated steatotic liver disease tryptophan
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